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10.1073/pnas.2116668118 http://scihub22266oqcxt.onion/10.1073/pnas.2116668118 34903581!8719879!34903581     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2021 ; 118 (52): ä Nephropedia Template TP {{tp|p=34903581|t=2021. SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes |pdf=|usr=}}{{34903581}} gab.com Text SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34903581 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease (COVID-19), continues to be a pressing health concern. In this study, we investigated the impact of SARS-CoV-2 infection on host microRNA (miRNA) populations in three human lung-derived cell lines, as well as in nasopharyngeal swabs from SARS-CoV-2-infected individuals. We did not detect any major and consistent differences in host miRNA levels after SARS-CoV-2 infection. However, we unexpectedly discovered a viral miRNA-like small RNA, named CoV2-miR-O7a (for SARS-CoV-2 miRNA-like ORF7a-derived small RNA). Its abundance ranges from low to moderate as compared to host miRNAs and it associates with Argonaute proteins-core components of the RNA interference pathway. We identify putative targets for CoV2-miR-O7a, including Basic Leucine Zipper ATF-Like Transcription Factor 2 (BATF2), which participates in interferon signaling. We demonstrate that CoV2-miR-O7a production relies on cellular machinery, yet is independent of Drosha protein, and is enhanced by the presence of a strong and evolutionarily conserved hairpin formed within the ORF7a sequence. Twit Text FOAVip SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34903581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34903581 #FOAvip English Wikipedia <ref>{{Cite pmid|34903581}}</ref> SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes #MMPMID34903581 Pawlica P; Yario TA; White S; Wang J; Moss WN; Hui P; Vinetz JM; Steitz JA Proc Natl Acad Sci U S A 2021[Dec]; 118 (52): ä PMID34903581show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease (COVID-19), continues to be a pressing health concern. In this study, we investigated the impact of SARS-CoV-2 infection on host microRNA (miRNA) populations in three human lung-derived cell lines, as well as in nasopharyngeal swabs from SARS-CoV-2-infected individuals. We did not detect any major and consistent differences in host miRNA levels after SARS-CoV-2 infection. However, we unexpectedly discovered a viral miRNA-like small RNA, named CoV2-miR-O7a (for SARS-CoV-2 miRNA-like ORF7a-derived small RNA). Its abundance ranges from low to moderate as compared to host miRNAs and it associates with Argonaute proteins-core components of the RNA interference pathway. We identify putative targets for CoV2-miR-O7a, including Basic Leucine Zipper ATF-Like Transcription Factor 2 (BATF2), which participates in interferon signaling. We demonstrate that CoV2-miR-O7a production relies on cellular machinery, yet is independent of Drosha protein, and is enhanced by the presence of a strong and evolutionarily conserved hairpin formed within the ORF7a sequence. |*Gene Expression Regulation, Viral[MESH] |COVID-19/metabolism/virology[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |RNA, Small Untranslated/genetics/*metabolism[MESH] |RNA, Viral/genetics/*metabolism[MESH] |SARS-CoV-2/genetics/*metabolism[MESH]SARS-CoV-2 expresses a microRNA-like small RNA able to selectively rep(epmc).pdf DeepDyve Pubget Overpricing