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10.3389/fimmu.2021.700705 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.700705 34899680!8652259!34899680     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34899680&cmd=llinks): Failed to open stream: HTTP request failed! 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Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs |pdf=|usr=}}{{34899680}} gab.com Text Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34899680 #FOAvip A novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), arose late in 2019, with disease pathology ranging from asymptomatic to severe respiratory distress with multi-organ failure requiring mechanical ventilator support. It has been found that SARS-CoV-2 infection drives intracellular complement activation in lung cells that tracks with disease severity. However, the cellular and molecular mechanisms responsible remain unclear. To shed light on the potential mechanisms, we examined publicly available RNA-Sequencing data using CIBERSORTx and conducted a Ingenuity Pathway Analysis to address this knowledge gap. In complement to these findings, we used bioinformatics tools to analyze publicly available RNA sequencing data and found that upregulation of complement may be leading to a downregulation of T-cell activity in lungs of severe COVID-19 patients. Thus, targeting treatments aimed at the modulation of classical complement and T-cell activity may help alleviate the proinflammatory effects of COVID-19, reduce lung pathology, and increase the survival of COVID-19 patients. Twit Text FOAVip Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34899680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34899680 #FOAvip English Wikipedia <ref>{{Cite pmid|34899680}}</ref> Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs #MMPMID34899680 Howell MC; Green R; McGill AR; Kahlil RM; Dutta R; Mohapatra SS; Mohapatra S Front Immunol 2021[]; 12 (ä): 700705 PMID34899680show ga A novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), arose late in 2019, with disease pathology ranging from asymptomatic to severe respiratory distress with multi-organ failure requiring mechanical ventilator support. It has been found that SARS-CoV-2 infection drives intracellular complement activation in lung cells that tracks with disease severity. However, the cellular and molecular mechanisms responsible remain unclear. To shed light on the potential mechanisms, we examined publicly available RNA-Sequencing data using CIBERSORTx and conducted a Ingenuity Pathway Analysis to address this knowledge gap. In complement to these findings, we used bioinformatics tools to analyze publicly available RNA sequencing data and found that upregulation of complement may be leading to a downregulation of T-cell activity in lungs of severe COVID-19 patients. Thus, targeting treatments aimed at the modulation of classical complement and T-cell activity may help alleviate the proinflammatory effects of COVID-19, reduce lung pathology, and increase the survival of COVID-19 patients. |COVID-19/*genetics/immunology/virology[MESH] |Complement Activation/*genetics[MESH] |Complement System Proteins/*genetics[MESH] |Gene Expression Profiling/*methods[MESH] |Gene Regulatory Networks/genetics[MESH] |Humans[MESH] |Intracellular Space/genetics[MESH] |Lung/immunology/*metabolism/microbiology[MESH] |Lymphocyte Count[MESH] |SARS-CoV-2/physiology[MESH] |T-Lymphocyte Subsets/metabolism[MESH]Activation of Intracellular Complement in Lungs of Patients With Sever(epmc).pdf DeepDyve Pubget Overpricing