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10.1177/11769343211064616 http://scihub22266oqcxt.onion/10.1177/11769343211064616 34898980!8655444!34898980     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Evol+Bioinform+Online 2021 ; 17 (ä): 11769343211064616 Nephropedia Template TP {{tp|p=34898980|t=2021. Evolutionary Dynamics of Indels in SARS-CoV-2 Spike Glycoprotein |pdf=|usr=}}{{34898980}} gab.com Text Evolutionary Dynamics of Indels in SARS-CoV-2 Spike Glycoprotein JO: Evol Bioinform Online http://www.kidney.de/pget.php?&tw=1&pmid=34898980 #FOAvip SARS-CoV-2, responsible for the current COVID-19 pandemic that claimed over 5.0 million lives, belongs to a class of enveloped viruses that undergo quick evolutionary adjustments under selection pressure. Numerous variants have emerged in SARS-CoV-2, posing a serious challenge to the global vaccination effort and COVID-19 management. The evolutionary dynamics of this virus are only beginning to be explored. In this work, we have analysed 1.79 million spike glycoprotein sequences of SARS-CoV-2 and found that the virus is fine-tuning the spike with numerous amino acid insertions and deletions (indels). Indels seem to have a selective advantage as the proportions of sequences with indels steadily increased over time, currently at over 89%, with similar trends across countries/variants. There were as many as 420 unique indel positions and 447 unique combinations of indels. Despite their high frequency, indels resulted in only minimal alteration of N-glycosylation sites, including both gain and loss. As indels and point mutations are positively correlated and sequences with indels have significantly more point mutations, they have implications in the evolutionary dynamics of the SARS-CoV-2 spike glycoprotein. Twit Text FOAVip Evolutionary Dynamics of Indels in SARS-CoV-2 Spike Glycoprotein ????Evol Bioinform Online http://www.kidney.de/pget.php?&tw=1&pmid=34898980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34898980 #FOAvip English Wikipedia <ref>{{Cite pmid|34898980}}</ref> Evolutionary Dynamics of Indels in SARS-CoV-2 Spike Glycoprotein #MMPMID34898980 Rao RSP; Ahsan N; Xu C; Su L; Verburgt J; Fornelli L; Kihara D; Xu D Evol Bioinform Online 2021[]; 17 (ä): 11769343211064616 PMID34898980show ga SARS-CoV-2, responsible for the current COVID-19 pandemic that claimed over 5.0 million lives, belongs to a class of enveloped viruses that undergo quick evolutionary adjustments under selection pressure. Numerous variants have emerged in SARS-CoV-2, posing a serious challenge to the global vaccination effort and COVID-19 management. The evolutionary dynamics of this virus are only beginning to be explored. In this work, we have analysed 1.79 million spike glycoprotein sequences of SARS-CoV-2 and found that the virus is fine-tuning the spike with numerous amino acid insertions and deletions (indels). Indels seem to have a selective advantage as the proportions of sequences with indels steadily increased over time, currently at over 89%, with similar trends across countries/variants. There were as many as 420 unique indel positions and 447 unique combinations of indels. Despite their high frequency, indels resulted in only minimal alteration of N-glycosylation sites, including both gain and loss. As indels and point mutations are positively correlated and sequences with indels have significantly more point mutations, they have implications in the evolutionary dynamics of the SARS-CoV-2 spike glycoprotein. äEvolutionary Dynamics of Indels in SARS-CoV-2 Spike Glycoprotein (epmc).pdf DeepDyve Pubget Overpricing