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10.1093/ije/dyab254 http://scihub22266oqcxt.onion/10.1093/ije/dyab254 34894230!8689860!34894230     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34894230&cmd=llinks): Failed to open stream: HTTP request failed! 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Smoking and severe illness in hospitalized COVID-19 patients in Japan |pdf=|usr=}}{{34894230}} gab.com Text Smoking and severe illness in hospitalized COVID-19 patients in Japan JO: Int J Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=34894230 #FOAvip BACKGROUND: The aim of this study was to identify associations between smoking status and the severity of COVID-19, using a large-scale data registry of hospitalized COVID-19 patients in Japan (COVIREGI-JP), and to explore the reasons for the inconsistent results previously reported on this subject. METHODS: The analysis included 17 666 COVID-19 inpatients aged 20-89 years (10 250 men and 7416 women). We graded the severity of COVID-19 (grades 0 to 5) according to the most intensive treatment required during hospitalization. The smoking status of severe grades 3/4/5 (invasive mechanical ventilation/extracorporeal membrane oxygenation/death) and separately of grade 5 (death) were compared with that of grade 0 (no oxygen, reference group) using multiple logistic regression. Results were expressed as odds ratios (OR) and 95% confidence intervals (CI) adjusted for age and other factors considering the potential intermediate effects of comorbidities. RESULTS: Among men, former smoking significantly increased the risk of grade 3/4/5 and grade 5, using grade 0 as a reference group, with age- and admission-date-adjusted ORs (95% CI) of 1.51 (1.18-1.93) and 1.65 (1.22-2.24), respectively. An additional adjustment for comorbidities weakened the ORs. Similar results were seen for women. Current smoking did not significantly increase the risk of grade 3/4/5 and grade 5 in either sex. CONCLUSIONS: The severity of COVID-19 was not associated with current or former smoking per se but with the comorbidities caused by smoking. Thus, smoking cessation is likely to be a key factor for preventing smoking-related disease and hence for reducing the risk of severe COVID-19. Twit Text FOAVip Smoking and severe illness in hospitalized COVID-19 patients in Japan ????Int J Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=34894230 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34894230 #FOAvip English Wikipedia <ref>{{Cite pmid|34894230}}</ref> Smoking and severe illness in hospitalized COVID-19 patients in Japan #MMPMID34894230 Matsushita Y; Yokoyama T; Hayakawa K; Matsunaga N; Ohtsu H; Saito S; Terada M; Suzuki S; Morioka S; Kutsuna S; Mizoue T; Hara H; Kimura A; Ohmagari N Int J Epidemiol 2022[Aug]; 51 (4): 1078-1087 PMID34894230show ga BACKGROUND: The aim of this study was to identify associations between smoking status and the severity of COVID-19, using a large-scale data registry of hospitalized COVID-19 patients in Japan (COVIREGI-JP), and to explore the reasons for the inconsistent results previously reported on this subject. METHODS: The analysis included 17 666 COVID-19 inpatients aged 20-89 years (10 250 men and 7416 women). We graded the severity of COVID-19 (grades 0 to 5) according to the most intensive treatment required during hospitalization. The smoking status of severe grades 3/4/5 (invasive mechanical ventilation/extracorporeal membrane oxygenation/death) and separately of grade 5 (death) were compared with that of grade 0 (no oxygen, reference group) using multiple logistic regression. Results were expressed as odds ratios (OR) and 95% confidence intervals (CI) adjusted for age and other factors considering the potential intermediate effects of comorbidities. RESULTS: Among men, former smoking significantly increased the risk of grade 3/4/5 and grade 5, using grade 0 as a reference group, with age- and admission-date-adjusted ORs (95% CI) of 1.51 (1.18-1.93) and 1.65 (1.22-2.24), respectively. An additional adjustment for comorbidities weakened the ORs. Similar results were seen for women. Current smoking did not significantly increase the risk of grade 3/4/5 and grade 5 in either sex. CONCLUSIONS: The severity of COVID-19 was not associated with current or former smoking per se but with the comorbidities caused by smoking. Thus, smoking cessation is likely to be a key factor for preventing smoking-related disease and hence for reducing the risk of severe COVID-19. |*COVID-19[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Japan/epidemiology[MESH] |Male[MESH] |SARS-CoV-2[MESH]Smoking and severe illness in hospitalized COVID-19 patients in Japan (epmc).pdf DeepDyve Pubget Overpricing