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10.1038/s41467-021-27544-6 http://scihub22266oqcxt.onion/10.1038/s41467-021-27544-6 34893640!8664884!34893640     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 7222 Nephropedia Template TP {{tp|p=34893640|t=2021. Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction |pdf=|usr=}}{{34893640}} gab.com Text Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34893640 #FOAvip Multi-system Inflammatory Syndrome in Children (MIS-C) is a major complication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in pediatric patients. Weeks after an often mild or asymptomatic initial infection with SARS-CoV-2 children may present with a severe shock-like picture and marked inflammation. Children with MIS-C present with varying degrees of cardiovascular and hyperinflammatory symptoms. Here we perform a comprehensive analysis of the plasma proteome of more than 1400 proteins in children with SARS-CoV-2. We hypothesize that the proteome would reflect heterogeneity in hyperinflammation and vascular injury, and further identify pathogenic mediators of disease. We show that protein signatures demonstrate overlap between MIS-C, and the inflammatory syndromes macrophage activation syndrome (MAS) and thrombotic microangiopathy (TMA). We demonstrate that PLA2G2A is an important marker of MIS-C that associates with TMA. We find that IFNgamma responses are dysregulated in MIS-C patients, and that IFNgamma levels delineate clinical heterogeneity. Twit Text FOAVip Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34893640 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34893640 #FOAvip English Wikipedia <ref>{{Cite pmid|34893640}}</ref> Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction #MMPMID34893640 Diorio C; Shraim R; Vella LA; Giles JR; Baxter AE; Oldridge DA; Canna SW; Henrickson SE; McNerney KO; Balamuth F; Burudpakdee C; Lee J; Leng T; Farrel A; Lambert MP; Sullivan KE; Wherry EJ; Teachey DT; Bassiri H; Behrens EM Nat Commun 2021[Dec]; 12 (1): 7222 PMID34893640show ga Multi-system Inflammatory Syndrome in Children (MIS-C) is a major complication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in pediatric patients. Weeks after an often mild or asymptomatic initial infection with SARS-CoV-2 children may present with a severe shock-like picture and marked inflammation. Children with MIS-C present with varying degrees of cardiovascular and hyperinflammatory symptoms. Here we perform a comprehensive analysis of the plasma proteome of more than 1400 proteins in children with SARS-CoV-2. We hypothesize that the proteome would reflect heterogeneity in hyperinflammation and vascular injury, and further identify pathogenic mediators of disease. We show that protein signatures demonstrate overlap between MIS-C, and the inflammatory syndromes macrophage activation syndrome (MAS) and thrombotic microangiopathy (TMA). We demonstrate that PLA2G2A is an important marker of MIS-C that associates with TMA. We find that IFNgamma responses are dysregulated in MIS-C patients, and that IFNgamma levels delineate clinical heterogeneity. |*Proteome[MESH] |Biomarkers[MESH] |COVID-19/*complications/metabolism/pathology[MESH] |Case-Control Studies[MESH] |Chemokine CXCL9[MESH] |Child[MESH] |Endothelium, Vascular/*physiopathology[MESH] |Group II Phospholipases A2[MESH] |Humans[MESH] |Inflammation[MESH] |Interferon-gamma/*immunology[MESH] |Interleukin-10[MESH] |Proteomics[MESH] |Systemic Inflammatory Response Syndrome/metabolism/*pathology[MESH]Proteomic profiling of MIS-C patients indicates heterogeneity relating(epmc).pdf DeepDyve Pubget Overpricing