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10.1038/s41392-021-00819-6 http://scihub22266oqcxt.onion/10.1038/s41392-021-00819-6 34893580!8661333!34893580     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Signal+Transduct+Target+Ther 2021 ; 6 (1): 418 Nephropedia Template TP {{tp|p=34893580|t=2021. Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks |pdf=|usr=}}{{34893580}} gab.com Text Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks JO: Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=34893580 #FOAvip The systemic processes involved in the manifestation of life-threatening COVID-19 and in disease recovery are still incompletely understood, despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 infection. To define hallmarks of severe COVID-19 in acute disease (n = 58) and in disease recovery in convalescent patients (n = 28) from Hannover Medical School, we used flow cytometry and proteomics data with unsupervised clustering analyses. In our observational study, we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury. ICU patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific antibodies. The core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe COVID-19. Changes within this signature were associated with either disease progression or recovery. In summary, our data suggest that besides a strong inflammatory response, severe COVID-19 is driven by endothelial activation and barrier disruption, whereby recovery depends on the regeneration of the endothelial integrity. Twit Text FOAVip Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks ????Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=34893580 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34893580 #FOAvip English Wikipedia <ref>{{Cite pmid|34893580}}</ref> Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks #MMPMID34893580 Ruhl L; Pink I; Kuhne JF; Beushausen K; Keil J; Christoph S; Sauer A; Boblitz L; Schmidt J; David S; Jack HM; Roth E; Cornberg M; Schulz TF; Welte T; Hoper MM; Falk CS Signal Transduct Target Ther 2021[Dec]; 6 (1): 418 PMID34893580show ga The systemic processes involved in the manifestation of life-threatening COVID-19 and in disease recovery are still incompletely understood, despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 infection. To define hallmarks of severe COVID-19 in acute disease (n = 58) and in disease recovery in convalescent patients (n = 28) from Hannover Medical School, we used flow cytometry and proteomics data with unsupervised clustering analyses. In our observational study, we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury. ICU patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific antibodies. The core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe COVID-19. Changes within this signature were associated with either disease progression or recovery. In summary, our data suggest that besides a strong inflammatory response, severe COVID-19 is driven by endothelial activation and barrier disruption, whereby recovery depends on the regeneration of the endothelial integrity. |Antibodies, Viral/*blood[MESH] |Biomarkers/blood[MESH] |Blood Proteins/*metabolism[MESH] |C-Reactive Protein/metabolism[MESH] |COVID-19/*diagnosis/immunology/mortality/virology[MESH] |Chemokine CXCL10/blood[MESH] |Chemokine CXCL9/blood[MESH] |Cluster Analysis[MESH] |Convalescence[MESH] |Cytokine Release Syndrome/*diagnosis/immunology/mortality/virology[MESH] |Disease Progression[MESH] |Endothelium, Vascular/immunology/*virology[MESH] |Granulocytes/immunology/virology[MESH] |Hematopoietic Cell Growth Factors/blood[MESH] |Hepatocyte Growth Factor/blood[MESH] |Humans[MESH] |Intensive Care Units[MESH] |Interleukin-12 Subunit p40/blood[MESH] |Interleukin-6/blood[MESH] |Interleukin-8/blood[MESH] |Killer Cells, Natural/immunology/virology[MESH] |Lectins, C-Type/blood[MESH] |Lymphopenia/*diagnosis/immunology/mortality/virology[MESH] |Plasma Cells/immunology/virology[MESH] |SARS-CoV-2/*pathogenicity[MESH] |Survival Analysis[MESH]Endothelial dysfunction contributes to severe COVID-19 in combination (epmc).pdf DeepDyve Pubget Overpricing