Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


suck pdf from google scholar
unlimited free pdf from europmc34889942    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi

Nephropedia Template TP Text

Twit Text FOAVip

Twit Text #

English Wikipedia

  • Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge #MMPMID34889942
  • Hilligan KL; Namasivayam S; Clancy CS; O'Mard D; Oland SD; Robertson SJ; Baker PJ; Castro E; Garza NL; Lafont BAP; Johnson R; Ronchese F; Mayer-Barber KD; Best SM; Sher A
  • J Exp Med 2022[Feb]; 219 (2): ä PMID34889942show ga
  • In addition to providing partial protection against pediatric tuberculosis, vaccination with bacille Calmette-Guerin (BCG) has been reported to confer nonspecific resistance to unrelated pulmonary pathogens, a phenomenon attributed to the induction of long-lasting alterations within the myeloid cell compartment. Here, we demonstrate that intravenous, but not subcutaneous, inoculation of BCG protects human-ACE2 transgenic mice against lethal challenge with SARS-CoV-2 (SCV2) and results in reduced viral loads in non-transgenic animals infected with an alpha variant. The observed increase in host resistance was associated with reductions in SCV2-induced tissue pathology, inflammatory cell recruitment, and cytokine production that multivariate analysis revealed as only partially related to diminished viral load. We propose that this protection stems from BCG-induced alterations in the composition and function of the pulmonary cellular compartment that impact the innate response to the virus and ensuing immunopathology. While intravenous BCG vaccination is not a clinically acceptable practice, our findings provide an experimental model for identifying mechanisms by which nonspecific stimulation of the pulmonary immune response promotes host resistance to SCV2 lethality.
  • |Administration, Intravenous[MESH]
  • |Angiotensin-Converting Enzyme 2/metabolism[MESH]
  • |Animals[MESH]
  • |BCG Vaccine/*immunology[MESH]
  • |COVID-19/*immunology[MESH]
  • |Chemokines/metabolism[MESH]
  • |Humans[MESH]
  • |Inflammation/pathology[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Mice, Transgenic[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Viral Load[MESH]

  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    ä 2.219 2022