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10.1038/s41556-021-00805-8 http://scihub22266oqcxt.onion/10.1038/s41556-021-00805-8 34887515!8656144!34887515     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34887515.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Cell+Biol 2021 ; 23 (12): 1240-1254 Nephropedia Template TP {{tp|p=34887515|t=2021. Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets |pdf=|usr=}}{{34887515}} gab.com Text Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34887515 #FOAvip Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular nanoparticle, termed supermere. Supermeres are morphologically distinct from exomeres and display a markedly greater uptake in vivo compared with small extracellular vesicles and exomeres. The protein and RNA composition of supermeres differs from small extracellular vesicles and exomeres. Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and AGO2), Alzheimer's disease (APP) and cardiovascular disease (ACE2, ACE and PCSK9). The majority of extracellular RNA is associated with supermeres rather than small extracellular vesicles and exomeres. Cancer-derived supermeres increase lactate secretion, transfer cetuximab resistance and decrease hepatic lipids and glycogen in vivo. This study identifies a distinct functional nanoparticle replete with potential circulating biomarkers and therapeutic targets for a host of human diseases. Twit Text FOAVip Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34887515 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34887515 #FOAvip English Wikipedia <ref>{{Cite pmid|34887515}}</ref> Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets #MMPMID34887515 Zhang Q; Jeppesen DK; Higginbotham JN; Graves-Deal R; Trinh VQ; Ramirez MA; Sohn Y; Neininger AC; Taneja N; McKinley ET; Niitsu H; Cao Z; Evans R; Glass SE; Ray KC; Fissell WH; Hill S; Rose KL; Huh WJ; Washington MK; Ayers GD; Burnette DT; Sharma S; Rome LH; Franklin JL; Lee YA; Liu Q; Coffey RJ Nat Cell Biol 2021[Dec]; 23 (12): 1240-1254 PMID34887515show ga Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular nanoparticle, termed supermere. Supermeres are morphologically distinct from exomeres and display a markedly greater uptake in vivo compared with small extracellular vesicles and exomeres. The protein and RNA composition of supermeres differs from small extracellular vesicles and exomeres. Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and AGO2), Alzheimer's disease (APP) and cardiovascular disease (ACE2, ACE and PCSK9). The majority of extracellular RNA is associated with supermeres rather than small extracellular vesicles and exomeres. Cancer-derived supermeres increase lactate secretion, transfer cetuximab resistance and decrease hepatic lipids and glycogen in vivo. This study identifies a distinct functional nanoparticle replete with potential circulating biomarkers and therapeutic targets for a host of human diseases. |Alzheimer Disease/pathology[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Biological Transport/physiology[MESH] |Biomarkers/metabolism[MESH] |COVID-19/pathology[MESH] |Cardiovascular Diseases/pathology[MESH] |Cell Communication/physiology[MESH] |Cell Line, Tumor[MESH] |Extracellular Vesicles/*metabolism[MESH] |HeLa Cells[MESH] |Humans[MESH] |Lactic Acid/metabolism[MESH] |MicroRNAs/genetics/*metabolism[MESH] |Nanoparticles/classification/*metabolism[MESH] |Neoplasms/pathology[MESH]Supermeres are functional extracellular nanoparticles replete with dis(epmc).pdf DeepDyve Pubget Overpricing