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10.3390/ijms222313009

http://scihub22266oqcxt.onion/10.3390/ijms222313009
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34884813!8658039!34884813
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suck abstract from ncbi


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pmid34884813      Int+J+Mol+Sci 2021 ; 22 (23): ä
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  • Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases #MMPMID34884813
  • Tang XD; Ji TT; Dong JR; Feng H; Chen FQ; Chen X; Zhao HY; Chen DK; Ma WT
  • Int J Mol Sci 2021[Nov]; 22 (23): ä PMID34884813show ga
  • Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, "multi-omics" immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.
  • |Anti-Inflammatory Agents/therapeutic use[MESH]
  • |Bacteria/immunology[MESH]
  • |Bacterial Infections/pathology[MESH]
  • |COVID-19/*pathology[MESH]
  • |Cytokine Release Syndrome/*drug therapy/*pathology[MESH]
  • |Cytokines/*blood/metabolism[MESH]
  • |Humans[MESH]
  • |Inflammation/pathology[MESH]
  • |Macrophages/immunology[MESH]
  • |SARS-CoV-2/immunology[MESH]


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