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10.3390/ijms222312800 http://scihub22266oqcxt.onion/10.3390/ijms222312800 34884604!8657827!34884604     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (23): ä Nephropedia Template TP {{tp|p=34884604|t=2021. Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarction to COVID-19 |pdf=|usr=}}{{34884604}} gab.com Text Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarction to COVID-19 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34884604 #FOAvip Alternative branches of the classical renin-angiotensin-aldosterone system (RAS) represent an important cascade in which angiotensin 2 (AngII) undergoes cleavage via the action of the angiotensin-converting enzyme 2 (ACE2) with subsequent production of Ang(1-7) and other related metabolites eliciting its effects via Mas receptor activation. Generally, this branch of the RAS system is described as its non-canonical alternative arm with counterbalancing actions to the classical RAS, conveying vasodilation, anti-inflammatory, anti-remodeling and anti-proliferative effects. The implication of this branch was proposed for many different diseases, ranging from acute cardiovascular conditions, through chronic respiratory diseases to cancer, nonetheless, hypoxia is one of the most prominent common factors discussed in conjugation with the changes in the activity of alternative RAS branches. The aim of this review is to bring complex insights into the mechanisms behind the various forms of hypoxic insults on the activity of alternative RAS branches based on the different duration of stimuli and causes (acute vs. intermittent vs. chronic), localization and tissue (heart vs. vessels vs. lungs) and clinical relevance of studied phenomenon (experimental vs. clinical condition). Moreover, we provide novel insights into the future strategies utilizing the alternative RAS as a diagnostic tool as well as a promising pharmacological target in serious hypoxia-associated cardiovascular and cardiopulmonary diseases. Twit Text FOAVip Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarction to COVID-19 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34884604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34884604 #FOAvip English Wikipedia <ref>{{Cite pmid|34884604}}</ref> Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarction to COVID-19 #MMPMID34884604 Rajtik T; Galis P; Bartosova L; Paulis L; Goncalvesova E; Klimas J Int J Mol Sci 2021[Nov]; 22 (23): ä PMID34884604show ga Alternative branches of the classical renin-angiotensin-aldosterone system (RAS) represent an important cascade in which angiotensin 2 (AngII) undergoes cleavage via the action of the angiotensin-converting enzyme 2 (ACE2) with subsequent production of Ang(1-7) and other related metabolites eliciting its effects via Mas receptor activation. Generally, this branch of the RAS system is described as its non-canonical alternative arm with counterbalancing actions to the classical RAS, conveying vasodilation, anti-inflammatory, anti-remodeling and anti-proliferative effects. The implication of this branch was proposed for many different diseases, ranging from acute cardiovascular conditions, through chronic respiratory diseases to cancer, nonetheless, hypoxia is one of the most prominent common factors discussed in conjugation with the changes in the activity of alternative RAS branches. The aim of this review is to bring complex insights into the mechanisms behind the various forms of hypoxic insults on the activity of alternative RAS branches based on the different duration of stimuli and causes (acute vs. intermittent vs. chronic), localization and tissue (heart vs. vessels vs. lungs) and clinical relevance of studied phenomenon (experimental vs. clinical condition). Moreover, we provide novel insights into the future strategies utilizing the alternative RAS as a diagnostic tool as well as a promising pharmacological target in serious hypoxia-associated cardiovascular and cardiopulmonary diseases. |*COVID-19[MESH] |*Myocardial Infarction[MESH] |*Renin-Angiotensin System[MESH] |Angiotensin I[MESH] |Angiotensin II/metabolism[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Animals[MESH] |Humans[MESH] |Hypoxia/*metabolism[MESH] |Lung[MESH] |Peptide Fragments[MESH]Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarct(epmc).pdf DeepDyve Pubget Overpricing