Engineered bacteria recycle tumor metabolic waste to boost immunotherapy #MMPMID34883059
Cubillos-Ruiz JR; Cubillos-Ruiz A
Cell Host Microbe 2021[Dec]; 29 (12): 1725-1727 PMID34883059show ga
A recent study published in Nature by Canale et al. (2021) shows that engineered probiotic bacteria can be used to augment the availability of nutrients required for optimal immune cell function in tumors. This approach enhances anti-tumor immunity and improves the efficacy of immunotherapy in mouse models of cancer.