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10.1038/s41556-021-00796-6 http://scihub22266oqcxt.onion/10.1038/s41556-021-00796-6 34876692!8650955!34876692     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34876692.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Cell+Biol 2021 ; 23 (12): 1314-1328 Nephropedia Template TP {{tp|p=34876692|t=2021. A single-cell transcriptomic landscape of the lungs of patients with COVID-19 |pdf=|usr=}}{{34876692}} gab.com Text A single-cell transcriptomic landscape of the lungs of patients with COVID-19 JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34876692 #FOAvip The lung is the primary organ targeted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), making respiratory failure a leading coronavirus disease 2019 (COVID-19)-related mortality. However, our cellular and molecular understanding of how SARS-CoV-2 infection drives lung pathology is limited. Here we constructed multi-omics and single-nucleus transcriptomic atlases of the lungs of patients with COVID-19, which integrate histological, transcriptomic and proteomic analyses. Our work reveals the molecular basis of pathological hallmarks associated with SARS-CoV-2 infection in different lung and infiltrating immune cell populations. We report molecular fingerprints of hyperinflammation, alveolar epithelial cell exhaustion, vascular changes and fibrosis, and identify parenchymal lung senescence as a molecular state of COVID-19 pathology. Moreover, our data suggest that FOXO3A suppression is a potential mechanism underlying the fibroblast-to-myofibroblast transition associated with COVID-19 pulmonary fibrosis. Our work depicts a comprehensive cellular and molecular atlas of the lungs of patients with COVID-19 and provides insights into SARS-CoV-2-related pulmonary injury, facilitating the identification of biomarkers and development of symptomatic treatments. Twit Text FOAVip A single-cell transcriptomic landscape of the lungs of patients with COVID-19 ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34876692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34876692 #FOAvip English Wikipedia <ref>{{Cite pmid|34876692}}</ref> A single-cell transcriptomic landscape of the lungs of patients with COVID-19 #MMPMID34876692 Wang S; Yao X; Ma S; Ping Y; Fan Y; Sun S; He Z; Shi Y; Sun L; Xiao S; Song M; Cai J; Li J; Tang R; Zhao L; Wang C; Wang Q; Zhao L; Hu H; Liu X; Sun G; Chen L; Pan G; Chen H; Li Q; Zhang P; Xu Y; Feng H; Zhao GG; Wen T; Yang Y; Huang X; Li W; Liu Z; Wang H; Wu H; Hu B; Ren Y; Zhou Q; Qu J; Zhang W; Liu GH; Bian XW Nat Cell Biol 2021[Dec]; 23 (12): 1314-1328 PMID34876692show ga The lung is the primary organ targeted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), making respiratory failure a leading coronavirus disease 2019 (COVID-19)-related mortality. However, our cellular and molecular understanding of how SARS-CoV-2 infection drives lung pathology is limited. Here we constructed multi-omics and single-nucleus transcriptomic atlases of the lungs of patients with COVID-19, which integrate histological, transcriptomic and proteomic analyses. Our work reveals the molecular basis of pathological hallmarks associated with SARS-CoV-2 infection in different lung and infiltrating immune cell populations. We report molecular fingerprints of hyperinflammation, alveolar epithelial cell exhaustion, vascular changes and fibrosis, and identify parenchymal lung senescence as a molecular state of COVID-19 pathology. Moreover, our data suggest that FOXO3A suppression is a potential mechanism underlying the fibroblast-to-myofibroblast transition associated with COVID-19 pulmonary fibrosis. Our work depicts a comprehensive cellular and molecular atlas of the lungs of patients with COVID-19 and provides insights into SARS-CoV-2-related pulmonary injury, facilitating the identification of biomarkers and development of symptomatic treatments. |Alveolar Epithelial Cells/metabolism/pathology/virology[MESH] |COVID-19/*genetics/metabolism[MESH] |Fibrosis/metabolism/pathology/virology[MESH] |Humans[MESH] |Lung/*metabolism/pathology/virology[MESH] |Proteomics/methods[MESH] |SARS-CoV-2/pathogenicity[MESH]A single-cell transcriptomic landscape of the lungs of patients with C(epmc).pdf DeepDyve Pubget Overpricing