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10.1186/s12967-021-03168-8 http://scihub22266oqcxt.onion/10.1186/s12967-021-03168-8 34876157!8649311!34876157     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34876157.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Transl+Med 2021 ; 19 (1): 501 Nephropedia Template TP {{tp|p=34876157|t=2021. Multi-omics approach to COVID-19: a domain-based literature review |pdf=|usr=}}{{34876157}} gab.com Text Multi-omics approach to COVID-19: a domain-based literature review JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=34876157 #FOAvip BACKGROUND: Omics data, driven by rapid advances in laboratory techniques, have been generated very quickly during the COVID-19 pandemic. Our aim is to use omics data to highlight the involvement of specific pathways, as well as that of cell types and organs, in the pathophysiology of COVID-19, and to highlight their links with clinical phenotypes of SARS-CoV-2 infection. METHODS: The analysis was based on the domain model, where for domain it is intended a conceptual repository, useful to summarize multiple biological pathways involved at different levels. The relevant domains considered in the analysis were: virus, pathways and phenotypes. An interdisciplinary expert working group was defined for each domain, to carry out an independent literature scoping review. RESULTS: The analysis revealed that dysregulated pathways of innate immune responses, (i.e., complement activation, inflammatory responses, neutrophil activation and degranulation, platelet degranulation) can affect COVID-19 progression and outcomes. These results are consistent with several clinical studies. CONCLUSIONS: Multi-omics approach may help to further investigate unknown aspects of the disease. However, the disease mechanisms are too complex to be explained by a single molecular signature and it is necessary to consider an integrated approach to identify hallmarks of severity. Twit Text FOAVip Multi-omics approach to COVID-19: a domain-based literature review ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=34876157 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34876157 #FOAvip English Wikipedia <ref>{{Cite pmid|34876157}}</ref> Multi-omics approach to COVID-19: a domain-based literature review #MMPMID34876157 Montaldo C; Messina F; Abbate I; Antonioli M; Bordoni V; Aiello A; Ciccosanti F; Colavita F; Farroni C; Najafi Fard S; Giombini E; Goletti D; Matusali G; Rozera G; Rueca M; Sacchi A; Piacentini M; Agrati C; Fimia GM; Capobianchi MR; Lauria FN; Ippolito G J Transl Med 2021[Dec]; 19 (1): 501 PMID34876157show ga BACKGROUND: Omics data, driven by rapid advances in laboratory techniques, have been generated very quickly during the COVID-19 pandemic. Our aim is to use omics data to highlight the involvement of specific pathways, as well as that of cell types and organs, in the pathophysiology of COVID-19, and to highlight their links with clinical phenotypes of SARS-CoV-2 infection. METHODS: The analysis was based on the domain model, where for domain it is intended a conceptual repository, useful to summarize multiple biological pathways involved at different levels. The relevant domains considered in the analysis were: virus, pathways and phenotypes. An interdisciplinary expert working group was defined for each domain, to carry out an independent literature scoping review. RESULTS: The analysis revealed that dysregulated pathways of innate immune responses, (i.e., complement activation, inflammatory responses, neutrophil activation and degranulation, platelet degranulation) can affect COVID-19 progression and outcomes. These results are consistent with several clinical studies. CONCLUSIONS: Multi-omics approach may help to further investigate unknown aspects of the disease. However, the disease mechanisms are too complex to be explained by a single molecular signature and it is necessary to consider an integrated approach to identify hallmarks of severity. |*COVID-19[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Pandemics[MESH]Multi-omics approach to COVID-19: a domain-based literature review (epmc).pdf DeepDyve Pubget Overpricing