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10.1016/j.xcrm.2021.100476 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100476 34873589!8636386!34873589     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (12): 100476 Nephropedia Template TP {{tp|p=34873589|t=2021. People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden |pdf=|usr=}}{{34873589}} gab.com Text People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34873589 #FOAvip Despite extensive analyses, there remains an urgent need to delineate immune cell states that contribute to mortality in people critically ill with COVID-19. Here, we present high-dimensional profiling of blood and respiratory samples from people with severe COVID-19 to examine the association between cell-linked molecular features and mortality outcomes. Peripheral transcriptional profiles by single-cell RNA sequencing (RNA-seq)-based deconvolution of immune states are associated with COVID-19 mortality. Further, persistently high levels of an interferon signaling module in monocytes over time lead to subsequent concerted upregulation of inflammatory cytokines. SARS-CoV-2-infected myeloid cells in the lower respiratory tract upregulate CXCL10, leading to a higher risk of death. Our analysis suggests a pivotal role for viral-infected myeloid cells and protracted interferon signaling in severe COVID-19. Twit Text FOAVip People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34873589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34873589 #FOAvip English Wikipedia <ref>{{Cite pmid|34873589}}</ref> People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden #MMPMID34873589 Cillo AR; Somasundaram A; Shan F; Cardello C; Workman CJ; Kitsios GD; Ruffin AT; Kunning S; Lampenfeld C; Onkar S; Grebinoski S; Deshmukh G; Methe B; Liu C; Nambulli S; Andrews LP; Duprex WP; Joglekar AV; Benos PV; Ray P; Ray A; McVerry BJ; Zhang Y; Lee JS; Das J; Singh H; Morris A; Bruno TC; Vignali DAA Cell Rep Med 2021[Dec]; 2 (12): 100476 PMID34873589show ga Despite extensive analyses, there remains an urgent need to delineate immune cell states that contribute to mortality in people critically ill with COVID-19. Here, we present high-dimensional profiling of blood and respiratory samples from people with severe COVID-19 to examine the association between cell-linked molecular features and mortality outcomes. Peripheral transcriptional profiles by single-cell RNA sequencing (RNA-seq)-based deconvolution of immune states are associated with COVID-19 mortality. Further, persistently high levels of an interferon signaling module in monocytes over time lead to subsequent concerted upregulation of inflammatory cytokines. SARS-CoV-2-infected myeloid cells in the lower respiratory tract upregulate CXCL10, leading to a higher risk of death. Our analysis suggests a pivotal role for viral-infected myeloid cells and protracted interferon signaling in severe COVID-19. |Aged[MESH] |COVID-19/blood/*immunology/*mortality/virology[MESH] |Critical Illness[MESH] |Cytokines/blood[MESH] |Gene Regulatory Networks[MESH] |Humans[MESH] |Inflammation[MESH] |Lung/*immunology/virology[MESH] |Models, Theoretical[MESH] |Monocytes/immunology[MESH] |Myeloid Cells/immunology[MESH] |Reproducibility of Results[MESH] |SARS-CoV-2/*pathogenicity[MESH]People critically ill with COVID-19 exhibit peripheral immune profiles(epmc).pdf DeepDyve Pubget Overpricing