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10.1038/s41577-021-00657-1 http://scihub22266oqcxt.onion/10.1038/s41577-021-00657-1 34873279!8647067!34873279     free     free     free       Nat+Rev+Immunol 2022 ; 22 (1): 7-18 Nephropedia Template TP {{tp|p=34873279|t=2022. The germinal centre B cell response to SARS-CoV-2 |pdf=|usr=}}{{34873279}} gab.com Text The germinal centre B cell response to SARS-CoV-2 JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34873279 #FOAvip The germinal centre (GC) response is critical for the generation of affinity-matured plasma cells and memory B cells capable of mediating long-term protective immunity. Understanding whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination elicits a GC response has profound implications for the capacity of responding B cells to contribute to protection against infection. However, direct assessment of the GC response in humans remains a major challenge. Here we summarize emerging evidence for the importance of the GC response in the establishment of durable and broad immunity against SARS-CoV-2 and discuss new approaches to modulate the GC response to better protect against newly emerging SARS-CoV-2 variants. We also discuss new findings showing that the GC B cell response persists in the draining lymph nodes for at least 6 months in some individuals following vaccination with SARS-CoV-2 mRNA-based vaccines. Twit Text FOAVip The germinal centre B cell response to SARS-CoV-2 ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34873279 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34873279 #FOAvip English Wikipedia <ref>{{Cite pmid|34873279}}</ref> The germinal centre B cell response to SARS-CoV-2 #MMPMID34873279 Laidlaw BJ; Ellebedy AH Nat Rev Immunol 2022[Jan]; 22 (1): 7-18 PMID34873279show ga The germinal centre (GC) response is critical for the generation of affinity-matured plasma cells and memory B cells capable of mediating long-term protective immunity. Understanding whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination elicits a GC response has profound implications for the capacity of responding B cells to contribute to protection against infection. However, direct assessment of the GC response in humans remains a major challenge. Here we summarize emerging evidence for the importance of the GC response in the establishment of durable and broad immunity against SARS-CoV-2 and discuss new approaches to modulate the GC response to better protect against newly emerging SARS-CoV-2 variants. We also discuss new findings showing that the GC B cell response persists in the draining lymph nodes for at least 6 months in some individuals following vaccination with SARS-CoV-2 mRNA-based vaccines. |Animals[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19 Vaccines/*immunology[MESH] |COVID-19/*immunology/prevention & control/*virology[MESH] |Germinal Center/*immunology[MESH] |Humans[MESH] |Memory B Cells/*immunology[MESH] |SARS-CoV-2/*immunology[MESH]The germinal centre B cell response to SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing