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10.1016/S2213-2600(21)00408-2

http://scihub22266oqcxt.onion/10.1016/S2213-2600(21)00408-2
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34871544!8641959!34871544
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suck abstract from ncbi


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pmid34871544      Lancet+Respir+Med 2022 ; 10 (1): 95-106
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  • Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19 #MMPMID34871544
  • Milross L; Majo J; Cooper N; Kaye PM; Bayraktar O; Filby A; Fisher AJ
  • Lancet Respir Med 2022[Jan]; 10 (1): 95-106 PMID34871544show ga
  • The lungs are the main site that is affected in severe COVID-19, and post-mortem lung tissue provides crucial insights into the pathophysiology of severe disease. From basic histology to state-of-the-art multiparameter digital pathology technologies, post-mortem lung tissue provides snapshots of tissue architecture, and resident and inflammatory cell phenotypes and composition at the time of death. Contrary to early assumptions that COVID-19 in the lungs is a uniform disease, post-mortem findings have established a high degree of disease heterogeneity. Classic diffuse alveolar damage represents just one phenotype, with disease divisible by early and late progression as well as by pathophysiological process. A distinct lung tissue state occurs with secondary infection; extrapulmonary causes of death might also originate from a pathological process in the lungs linked to microthrombosis. This heterogeneity of COVID-19 lung disease must be recognised in the management of patients and in the development of novel treatment strategies.
  • |*COVID-19/immunology/pathology[MESH]
  • |*Lung/pathology/physiopathology/virology[MESH]
  • |Autopsy[MESH]
  • |Fossils[MESH]
  • |Humans[MESH]
  • |Patient Acuity[MESH]


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