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10.3389/fcimb.2021.747816

http://scihub22266oqcxt.onion/10.3389/fcimb.2021.747816
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suck abstract from ncbi


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pmid34869058      Front+Cell+Infect+Microbiol 2021 ; 11 (ä): 747816
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  • A Pro-Inflammatory Gut Microbiome Characterizes SARS-CoV-2 Infected Patients and a Reduction in the Connectivity of an Anti-Inflammatory Bacterial Network Associates With Severe COVID-19 #MMPMID34869058
  • Reinold J; Farahpour F; Fehring C; Dolff S; Konik M; Korth J; van Baal L; Hoffmann D; Buer J; Witzke O; Westendorf AM; Kehrmann J
  • Front Cell Infect Microbiol 2021[]; 11 (ä): 747816 PMID34869058show ga
  • The gut microbiota contributes to maintaining human health and regulating immune responses. Severe COVID-19 illness is associated with a dysregulated pro-inflammatory immune response. The effect of SARS-CoV-2 on altering the gut microbiome and the relevance of the gut microbiome on COVID-19 severity needs to be clarified. In this prospective study, we analyzed the gut microbiome of 212 patients of a tertiary care hospital (117 patients infected with SARS-CoV-2 and 95 SARS-CoV-2 negative patients) using 16S rRNA gene sequencing of the V3-V4 region. Inflammatory markers and immune cells were quantified from blood. The gut microbiome in SARS-CoV-2 infected patients was characterized by a lower bacterial richness and distinct differences in the gut microbiome composition, including an enrichment of the phyla Proteobacteria and Bacteroidetes and a decrease of Actinobacteria compared to SARS-CoV-2 negative patients. The relative abundance of several genera including Bifidobacterium, Streptococcus and Collinsella was lower in SARS-CoV-2 positive patients while the abundance of Bacteroides and Enterobacteriaceae was increased. Higher pro-inflammatory blood markers and a lower CD8(+) T cell number characterized patients with severe COVID-19 illness. The gut microbiome of patients with severe/critical COVID-19 exhibited a lower abundance of butyrate-producing genera Faecalibacterium and Roseburia and a reduction in the connectivity of a distinct network of anti-inflammatory genera that was observed in patients with mild COVID-19 illness and in SARS-CoV-2 negative patients. Dysbiosis of the gut microbiome associated with a pro-inflammatory signature may contribute to the hyperinflammatory immune response characterizing severe COVID-19 illness.
  • |*COVID-19[MESH]
  • |*Gastrointestinal Microbiome[MESH]
  • |Anti-Inflammatory Agents[MESH]
  • |Humans[MESH]
  • |Prospective Studies[MESH]
  • |RNA, Ribosomal, 16S/genetics[MESH]


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