Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.3389/fimmu.2021.755579

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.755579
suck pdf from google scholar
34867988!8640185!34867988
unlimited free pdf from europmc34867988    free
PDF from PMC    free
html from PMC    free
PDF vom PMID34867988 :   free

suck abstract from ncbi

pmid34867988
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Severe Adaptive Immune Suppression May Be Why Patients With Severe COVID-19 Cannot Be Discharged From the ICU Even After Negative Viral Tests #MMPMID34867988
  • Zhou Y; Liao X; Song X; He M; Xiao F; Jin X; Xie X; Zhang Z; Wang B; Zhou C; Kang Y; Zhang W
  • Front Immunol 2021[]; 12 (ä): 755579 PMID34867988show ga
  • During the COVID-19 pandemic, a phenomenon emerged in which some patients with severe disease were critically ill and could not be discharged from the ICU even though they exhibited negative viral tests. To explore the underlying mechanism, we collected blood samples from these patients and analyzed the gene expression profiles of peripheral immune cells. We found that all enrolled patients, regardless of changes in genes related to different symptoms and inflammatory responses, showed universally and severely decreased expression of adaptive immunity-related genes, especially those related to T/B cell arms and HLA molecules, and that these patients exhibited long-term secondary infections. In addition, no significant change was found in the expression of classic immunosuppression molecules including PD-1, PD-L1, and CTLA-4, suggesting that the adaptive immune suppression may not be due to the change of these genes. According to the published literatures and our data, this adaptive immunosuppression is likely to be caused by the "dysregulated host response" to severe infection, similar to the immunosuppression that exists in other severely infected patients with sepsis.
  • |Adaptive Immunity/genetics/*immunology[MESH]
  • |Aged[MESH]
  • |COVID-19/diagnosis/genetics/*immunology[MESH]
  • |Coinfection/diagnosis/genetics/immunology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Cytokine Release Syndrome/genetics[MESH]
  • |Female[MESH]
  • |Gene Expression Profiling[MESH]
  • |Humans[MESH]
  • |Immune Tolerance/genetics/*immunology[MESH]
  • |Inflammation/genetics[MESH]
  • |Intensive Care Units[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Patient Discharge[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Smell/genetics[MESH]
  • |Taste/genetics[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    755579 ä.12 2021