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10.1111/sji.13125 http://scihub22266oqcxt.onion/10.1111/sji.13125 34861051!9286348!34861051     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Scand+J+Immunol 2022 ; 95 (3): e13125 Nephropedia Template TP {{tp|p=34861051|t=2022. High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19 |pdf=|usr=}}{{34861051}} gab.com Text High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19 JO: Scand J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34861051 #FOAvip Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU. Twit Text FOAVip High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19 ????Scand J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34861051 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34861051 #FOAvip English Wikipedia <ref>{{Cite pmid|34861051}}</ref> High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19 #MMPMID34861051 De Zuani M; Laznickova P; Tomaskova V; Dvoncova M; Forte G; Stokin GB; Sramek V; Helan M; Fric J Scand J Immunol 2022[Mar]; 95 (3): e13125 PMID34861051show ga Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU. |Aged[MESH] |CD4-CD8 Ratio/methods[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Female[MESH] |Humans[MESH] |Immunophenotyping/methods[MESH] |Intensive Care Units[MESH] |Lymphocyte Count/methods[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH]High CD4-to-CD8 ratio identifies an at-risk population susceptible to (epmc).pdf DeepDyve Pubget Overpricing