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10.1007/s00108-021-01209-4 http://scihub22266oqcxt.onion/10.1007/s00108-021-01209-4 34860258!8640964!34860258     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Internist+(Berl) 2022 ; 63 (1): 12-17 Nephropedia Template TP {{tp|p=34860258|t=2022. Neue Aspekte der Glukokortikoidsubstitution bei Nebennierenrindeninsuffizienz |pdf=|usr=}}{{34860258}} gab.com Text Neue Aspekte der Glukokortikoidsubstitution bei Nebennierenrindeninsuffizienz JO: Internist (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=34860258 #FOAvip BACKGROUND: Appropriate glucocorticoid dose adjustment in specific situations significantly impacts quality of life and performance of patients with adrenal insufficiency. It is also pivotal for the prevention of adrenal crisis. OBJECTIVES: Improving medical care for patients with adrenal insufficiency. MATERIALS AND METHODS: Selective literature research focussing on the most recent studies. RESULTS: Optimal glucocorticoid substitution aims at closely mimicking physiological fluctuations of cortisol levels. In recent years glucocorticoid preparations with modified pharmacokinetics have expanded the therapeutic arsenal. Adrenal crises occur with an incidence of 4.8-9.3 crises per 100 patient years. With a mortality of 0.5 per 100 patient years adrenal crisis is a life-threatening event. Therefore, it is of the utmost importance to adjust glucocorticoid dose in situations with increased cortisol demand in order to prevent as well as appropriately treat adrenal crisis. CONCLUSIONS: To prevent life-threatening adrenal crisis, patients, their families and medical staff require training. Twit Text FOAVip Neue Aspekte der Glukokortikoidsubstitution bei Nebennierenrindeninsuffizienz ????Internist (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=34860258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34860258 #FOAvip English Wikipedia <ref>{{Cite pmid|34860258}}</ref> Neue Aspekte der Glukokortikoidsubstitution bei Nebennierenrindeninsuffizienz #MMPMID34860258 Kienitz T; Meyer G Internist (Berl) 2022[Jan]; 63 (1): 12-17 PMID34860258show ga BACKGROUND: Appropriate glucocorticoid dose adjustment in specific situations significantly impacts quality of life and performance of patients with adrenal insufficiency. It is also pivotal for the prevention of adrenal crisis. OBJECTIVES: Improving medical care for patients with adrenal insufficiency. MATERIALS AND METHODS: Selective literature research focussing on the most recent studies. RESULTS: Optimal glucocorticoid substitution aims at closely mimicking physiological fluctuations of cortisol levels. In recent years glucocorticoid preparations with modified pharmacokinetics have expanded the therapeutic arsenal. Adrenal crises occur with an incidence of 4.8-9.3 crises per 100 patient years. With a mortality of 0.5 per 100 patient years adrenal crisis is a life-threatening event. Therefore, it is of the utmost importance to adjust glucocorticoid dose in situations with increased cortisol demand in order to prevent as well as appropriately treat adrenal crisis. CONCLUSIONS: To prevent life-threatening adrenal crisis, patients, their families and medical staff require training. |*Adrenal Insufficiency/diagnosis/drug therapy[MESH] |*Glucocorticoids/adverse effects[MESH] |Acute Disease[MESH] |Humans[MESH] |Hydrocortisone[MESH]Neue Aspekte der Glukokortikoidsubstitution bei Nebennierenrindeninsuf(epmc).pdf DeepDyve Pubget Overpricing