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10.1021/acschemneuro.1c00666 http://scihub22266oqcxt.onion/10.1021/acschemneuro.1c00666 34860005!8739828!34860005     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Neurosci 2022 ; 13 (1): 143-150 Nephropedia Template TP {{tp|p=34860005|t=2022. Interactions between SARS-CoV-2 N-Protein and alpha-Synuclein Accelerate Amyloid Formation |pdf=|usr=}}{{34860005}} gab.com Text Interactions between SARS-CoV-2 N-Protein and alpha-Synuclein Accelerate Amyloid Formation JO: ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=34860005 #FOAvip First cases that point at a correlation between SARS-CoV-2 infections and the development of Parkinson's disease (PD) have been reported. Currently, it is unclear if there is also a direct causal link between these diseases. To obtain first insights into a possible molecular relation between viral infections and the aggregation of alpha-synuclein protein into amyloid fibrils characteristic for PD, we investigated the effect of the presence of SARS-CoV-2 proteins on alpha-synuclein aggregation. We show, in test tube experiments, that SARS-CoV-2 spike protein (S-protein) has no effect on alpha-synuclein aggregation, while SARS-CoV-2 nucleocapsid protein (N-protein) considerably speeds up the aggregation process. We observe the formation of multiprotein complexes and eventually amyloid fibrils. Microinjection of N-protein in SH-SY5Y cells disturbed the alpha-synuclein proteostasis and increased cell death. Our results point toward direct interactions between the N-protein of SARS-CoV-2 and alpha-synuclein as molecular basis for the observed correlation between SARS-CoV-2 infections and Parkinsonism. Twit Text FOAVip Interactions between SARS-CoV-2 N-Protein and alpha-Synuclein Accelerate Amyloid Formation ????ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=34860005 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34860005 #FOAvip English Wikipedia <ref>{{Cite pmid|34860005}}</ref> Interactions between SARS-CoV-2 N-Protein and alpha-Synuclein Accelerate Amyloid Formation #MMPMID34860005 Semerdzhiev SA; Fakhree MAA; Segers-Nolten I; Blum C; Claessens MMAE ACS Chem Neurosci 2022[Jan]; 13 (1): 143-150 PMID34860005show ga First cases that point at a correlation between SARS-CoV-2 infections and the development of Parkinson's disease (PD) have been reported. Currently, it is unclear if there is also a direct causal link between these diseases. To obtain first insights into a possible molecular relation between viral infections and the aggregation of alpha-synuclein protein into amyloid fibrils characteristic for PD, we investigated the effect of the presence of SARS-CoV-2 proteins on alpha-synuclein aggregation. We show, in test tube experiments, that SARS-CoV-2 spike protein (S-protein) has no effect on alpha-synuclein aggregation, while SARS-CoV-2 nucleocapsid protein (N-protein) considerably speeds up the aggregation process. We observe the formation of multiprotein complexes and eventually amyloid fibrils. Microinjection of N-protein in SH-SY5Y cells disturbed the alpha-synuclein proteostasis and increased cell death. Our results point toward direct interactions between the N-protein of SARS-CoV-2 and alpha-synuclein as molecular basis for the observed correlation between SARS-CoV-2 infections and Parkinsonism. |*Amyloid/metabolism[MESH] |*alpha-Synuclein/metabolism[MESH] |COVID-19[MESH] |Coronavirus Nucleocapsid Proteins/*metabolism[MESH] |Humans[MESH] |Phosphoproteins/metabolism[MESH] |SARS-CoV-2[MESH]Interactions between SARS-CoV-2 N-Protein and alpha-Synuclein Accelera(epmc).pdf DeepDyve Pubget Overpricing