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10.3389/fimmu.2021.756262 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.756262 34858409!8632002!34858409     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34858409&cmd=llinks): Failed to open stream: HTTP request failed! 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Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19 |pdf=|usr=}}{{34858409}} gab.com Text Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34858409 #FOAvip A male sex bias has emerged in the COVID-19 pandemic, fitting to the sex-biased pattern in other viral infections. Males are 2.84 times more often admitted to the ICU and mortality is 1.39 times higher as a result of COVID-19. Various factors play a role in this, and novel studies suggest that the gene-dose of Toll-Like Receptor (TLR) 7 could contribute to the sex-skewed severity. TLR7 is one of the crucial pattern recognition receptors for SARS-CoV-2 ssRNA and the gene-dose effect is caused by X chromosome inactivation (XCI) escape. Female immune cells with TLR7 XCI escape have biallelic TLR7 expression and produce more type 1 interferon (IFN) upon TLR7 stimulation. In COVID-19, TLR7 in plasmacytoid dendritic cells is one of the pattern recognition receptors responsible for IFN production and a delayed IFN response has been associated with immunopathogenesis and mortality. Here, we provide a hypothesis that females may be protected to some extend against severe COVID-19, due to the biallelic TLR7 expression, allowing them to mount a stronger and more protective IFN response early after infection. Studies exploring COVID-19 treatment via the TLR7-mediated IFN pathway should consider this sex difference. Various factors such as age, sex hormones and escape modulation remain to be investigated concerning the TLR7 gene-dose effect. Twit Text FOAVip Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34858409 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34858409 #FOAvip English Wikipedia <ref>{{Cite pmid|34858409}}</ref> Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19 #MMPMID34858409 Spiering AE; de Vries TJ Front Immunol 2021[]; 12 (ä): 756262 PMID34858409show ga A male sex bias has emerged in the COVID-19 pandemic, fitting to the sex-biased pattern in other viral infections. Males are 2.84 times more often admitted to the ICU and mortality is 1.39 times higher as a result of COVID-19. Various factors play a role in this, and novel studies suggest that the gene-dose of Toll-Like Receptor (TLR) 7 could contribute to the sex-skewed severity. TLR7 is one of the crucial pattern recognition receptors for SARS-CoV-2 ssRNA and the gene-dose effect is caused by X chromosome inactivation (XCI) escape. Female immune cells with TLR7 XCI escape have biallelic TLR7 expression and produce more type 1 interferon (IFN) upon TLR7 stimulation. In COVID-19, TLR7 in plasmacytoid dendritic cells is one of the pattern recognition receptors responsible for IFN production and a delayed IFN response has been associated with immunopathogenesis and mortality. Here, we provide a hypothesis that females may be protected to some extend against severe COVID-19, due to the biallelic TLR7 expression, allowing them to mount a stronger and more protective IFN response early after infection. Studies exploring COVID-19 treatment via the TLR7-mediated IFN pathway should consider this sex difference. Various factors such as age, sex hormones and escape modulation remain to be investigated concerning the TLR7 gene-dose effect. |COVID-19 Drug Treatment[MESH] |COVID-19/*mortality/pathology[MESH] |Chromosomes, Human, X/genetics[MESH] |Critical Care/statistics & numerical data[MESH] |Dendritic Cells/immunology[MESH] |Female[MESH] |Gene Dosage/*genetics[MESH] |Humans[MESH] |Interferon Type I/*biosynthesis/immunology[MESH] |Male[MESH] |RNA, Viral/genetics[MESH] |Receptors, Pattern Recognition/genetics/metabolism[MESH] |Risk Factors[MESH] |SARS-CoV-2/immunology[MESH] |Sex Factors[MESH] |Signal Transduction/immunology[MESH] |Toll-Like Receptor 7/*genetics/*metabolism[MESH]Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVI(epmc).pdf DeepDyve Pubget Overpricing