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10.1371/journal.pone.0260360

http://scihub22266oqcxt.onion/10.1371/journal.pone.0260360
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suck abstract from ncbi


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pmid34855795      PLoS+One 2021 ; 16 (12): e0260360
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  • SARS-CoV-2 spike protein displays sequence similarities with paramyxovirus surface proteins; a bioinformatics study #MMPMID34855795
  • Ahmadi E; Zabihi MR; Hosseinzadeh R; Mohamed Khosroshahi L; Noorbakhsh F
  • PLoS One 2021[]; 16 (12): e0260360 PMID34855795show ga
  • Recent emergence of SARS-CoV-2 and associated COVID-19 pandemic have posed a great challenge for the scientific community. In this study, we performed bioinformatic analyses on SARS-CoV-2 protein sequences, trying to unravel potential molecular similarities between this newly emerged pathogen with non-coronavirus ssRNA viruses. Comparing the proteins of SARS-CoV-2 with non-coronavirus positive and negative strand ssRNA viruses revealed multiple sequence similarities between SARS-CoV-2 and non-coronaviruses, including similarities between RNA-dependent RNA-polymerases and helicases (two highly-conserved proteins). We also observed similarities between SARS-CoV-2 surface (i.e. spike) protein with paramyxovirus fusion proteins. This similarity was restricted to a segment of spike protein S2 subunit which is involved in cell fusion. We next analyzed spike proteins from SARS-CoV-2 "variants of concern" (VOCs) and "variants of interests" (VOIs) and found that some of these variants show considerably higher spike-fusion similarity with paramyxoviruses. The 'spike-fusion' similarity was also observed for some pathogenic coronaviruses other than SARS-CoV-2. Epitope analysis using experimentally verified data deposited in Immune Epitope Database (IEDB) revealed that several B cell epitopes as well as T cell and MHC binding epitopes map within the spike-fusion similarity region. These data indicate that there might be a degree of convergent evolution between SARS-CoV-2 and paramyxovirus surface proteins which could be of pathogenic and immunological importance.
  • |Epitopes/genetics[MESH]
  • |Humans[MESH]
  • |Paramyxoviridae/genetics[MESH]
  • |Phylogeny[MESH]
  • |Protein Structure, Tertiary[MESH]
  • |SARS-CoV-2/*genetics[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/*genetics[MESH]


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