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  • Patients presenting high fever with lymphadenopathy after COVID-19 vaccination were diagnosed with hemophagocytic lymphohistiocytosis #MMPMID34854350
  • Baek DW; Hwang S; Kim J; Lee JM; Cho HJ; Moon JH; Hwang N; Jeong JY; Lee SW; Sohn SK
  • Infect Dis (Lond) 2022[Apr]; 54 (4): 303-307 PMID34854350show ga
  • BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still continuing worldwide. Currently, two mRNA-based vaccines and two DNA vaccines using an adenovirus vector are representative vaccines. Since the SARS-CoV-2 vaccines began to be administered, a significant decrease in new infections and COVID-19-associated death has been reported. However, various adverse events from mild symptoms to death have also been described after vaccination. CASE DESCRIPTION: Patients with high fever and lymphadenopathy who are diagnosed with hemophagocytic lymphohistiocytosis (HLH) after COVID-19 vaccination are very rare, and there is no standard management guideline for these patients thus far. Herein, we described two cases of HLH after the administration of an mRNA-based vaccine and adenovirus vector vaccine. DISCUSSION: HLH is a life-threatening hyperinflammatory syndrome that occurs due to persistent stimulation of lymphocytes and histiocytes in various underlying conditions at all ages. Although the exact mechanisms and risk factors of COVID-19 vaccination-related HLH are still unknown, vigorous immune stimulation may trigger a huge cytokine storm, rarely resulting in HLH. It is important to note that early suspicion by clinicians can lower the mortality rate.
  • |*COVID-19[MESH]
  • |*Lymphadenopathy[MESH]
  • |*Lymphohistiocytosis, Hemophagocytic[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]
  • |Vaccination[MESH]

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  • suck abstract from ncbi

    303 4.54 2022