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10.1038/s41590-021-01084-z http://scihub22266oqcxt.onion/10.1038/s41590-021-01084-z 34853448!8709787!34853448     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2022 ; 23 (1): 50-61 Nephropedia Template TP {{tp|p=34853448|t=2022. An immunodominant NP(105-113)-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease |pdf=|usr=}}{{34853448}} gab.com Text An immunodominant NP(105-113)-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34853448 #FOAvip NP(105-113)-B*07:02-specific CD8(+) T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP(105-113)-B*07:02-specific T cell clones and single-cell sequencing were performed concurrently, with functional avidity and antiviral efficacy assessed using an in vitro SARS-CoV-2 infection system, and were correlated with T cell receptor usage, transcriptome signature and disease severity (acute n = 77, convalescent n = 52). We demonstrated a beneficial association of NP(105-113)-B*07:02-specific T cells in COVID-19 disease progression, linked with expansion of T cell precursors, high functional avidity and antiviral effector function. Broad immune memory pools were narrowed postinfection but NP(105-113)-B*07:02-specific T cells were maintained 6 months after infection with preserved antiviral efficacy to the SARS-CoV-2 Victoria strain, as well as Alpha, Beta, Gamma and Delta variants. Our data show that NP(105-113)-B*07:02-specific T cell responses associate with mild disease and high antiviral efficacy, pointing to inclusion for future vaccine design. Twit Text FOAVip An immunodominant NP(105-113)-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34853448 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34853448 #FOAvip English Wikipedia <ref>{{Cite pmid|34853448}}</ref> An immunodominant NP(105-113)-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease #MMPMID34853448 Peng Y; Felce SL; Dong D; Penkava F; Mentzer AJ; Yao X; Liu G; Yin Z; Chen JL; Lu Y; Wellington D; Wing PAC; Dominey-Foy DCC; Jin C; Wang W; Hamid MA; Fernandes RA; Wang B; Fries A; Zhuang X; Ashley N; Rostron T; Waugh C; Sopp P; Hublitz P; Beveridge R; Tan TK; Dold C; Kwok AJ; Rich-Griffin C; Dejnirattisa W; Liu C; Kurupati P; Nassiri I; Watson RA; Tong O; Taylor CA; Kumar Sharma P; Sun B; Curion F; Revale S; Garner LC; Jansen K; Ferreira RC; Attar M; Fry JW; Russell RA; Stauss HJ; James W; Townsend A; Ho LP; Klenerman P; Mongkolsapaya J; Screaton GR; Dendrou C; Sansom SN; Bashford-Rogers R; Chain B; Smith GL; McKeating JA; Fairfax BP; Bowness P; McMichael AJ; Ogg G; Knight JC; Dong T Nat Immunol 2022[Jan]; 23 (1): 50-61 PMID34853448show ga NP(105-113)-B*07:02-specific CD8(+) T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP(105-113)-B*07:02-specific T cell clones and single-cell sequencing were performed concurrently, with functional avidity and antiviral efficacy assessed using an in vitro SARS-CoV-2 infection system, and were correlated with T cell receptor usage, transcriptome signature and disease severity (acute n = 77, convalescent n = 52). We demonstrated a beneficial association of NP(105-113)-B*07:02-specific T cells in COVID-19 disease progression, linked with expansion of T cell precursors, high functional avidity and antiviral effector function. Broad immune memory pools were narrowed postinfection but NP(105-113)-B*07:02-specific T cells were maintained 6 months after infection with preserved antiviral efficacy to the SARS-CoV-2 Victoria strain, as well as Alpha, Beta, Gamma and Delta variants. Our data show that NP(105-113)-B*07:02-specific T cell responses associate with mild disease and high antiviral efficacy, pointing to inclusion for future vaccine design. |Aged[MESH] |Amino Acid Sequence[MESH] |Antibodies, Viral/immunology[MESH] |Antibody Affinity/immunology[MESH] |COVID-19/immunology/pathology[MESH] |Cell Line, Transformed[MESH] |Female[MESH] |Gene Expression Profiling[MESH] |HLA-B7 Antigen/*immunology[MESH] |Humans[MESH] |Immunodominant Epitopes/*immunology[MESH] |Immunologic Memory/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Nucleocapsid Proteins/*immunology[MESH] |Receptors, Antigen, T-Cell/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH] |T-Lymphocytes, Cytotoxic/*immunology[MESH]An immunodominant NP(105-113)-B*07:02 cytotoxic T cell response contro(epmc).pdf DeepDyve Pubget Overpricing