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10.1038/s41592-021-01318-w http://scihub22266oqcxt.onion/10.1038/s41592-021-01318-w 34845387!8665054!34845387     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34845387.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Methods 2021 ; 18 (12): 1477-1488 Nephropedia Template TP {{tp|p=34845387|t=2021. A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations |pdf=|usr=}}{{34845387}} gab.com Text A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations JO: Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=34845387 #FOAvip Emergence of new viral agents is driven by evolution of interactions between viral proteins and host targets. For instance, increased infectivity of SARS-CoV-2 compared to SARS-CoV-1 arose in part through rapid evolution along the interface between the spike protein and its human receptor ACE2, leading to increased binding affinity. To facilitate broader exploration of how pathogen-host interactions might impact transmission and virulence in the ongoing COVID-19 pandemic, we performed state-of-the-art interface prediction followed by molecular docking to construct a three-dimensional structural interactome between SARS-CoV-2 and human. We additionally carried out downstream meta-analyses to investigate enrichment of sequence divergence between SARS-CoV-1 and SARS-CoV-2 or human population variants along viral-human protein-interaction interfaces, predict changes in binding affinity by these mutations/variants and further prioritize drug repurposing candidates predicted to competitively bind human targets. We believe this resource ( http://3D-SARS2.yulab.org ) will aid in development and testing of informed hypotheses for SARS-CoV-2 etiology and treatments. Twit Text FOAVip A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations ????Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=34845387 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34845387 #FOAvip English Wikipedia <ref>{{Cite pmid|34845387}}</ref> A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations #MMPMID34845387 Wierbowski SD; Liang S; Liu Y; Chen Y; Gupta S; Andre NM; Lipkin SM; Whittaker GR; Yu H Nat Methods 2021[Dec]; 18 (12): 1477-1488 PMID34845387show ga Emergence of new viral agents is driven by evolution of interactions between viral proteins and host targets. For instance, increased infectivity of SARS-CoV-2 compared to SARS-CoV-1 arose in part through rapid evolution along the interface between the spike protein and its human receptor ACE2, leading to increased binding affinity. To facilitate broader exploration of how pathogen-host interactions might impact transmission and virulence in the ongoing COVID-19 pandemic, we performed state-of-the-art interface prediction followed by molecular docking to construct a three-dimensional structural interactome between SARS-CoV-2 and human. We additionally carried out downstream meta-analyses to investigate enrichment of sequence divergence between SARS-CoV-1 and SARS-CoV-2 or human population variants along viral-human protein-interaction interfaces, predict changes in binding affinity by these mutations/variants and further prioritize drug repurposing candidates predicted to competitively bind human targets. We believe this resource ( http://3D-SARS2.yulab.org ) will aid in development and testing of informed hypotheses for SARS-CoV-2 etiology and treatments. |*Virus Attachment[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Biological Evolution[MESH] |COVID-19/immunology/*virology[MESH] |Genetic Variation[MESH] |Humans[MESH] |Models, Molecular[MESH] |Molecular Structure[MESH] |Protein Conformation[MESH] |SARS-CoV-2/*genetics/*metabolism[MESH]A 3D structural SARS-CoV-2-human interactome to explore genetic and dr(epmc).pdf DeepDyve Pubget Overpricing