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suck abstract from ncbi

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  • Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot #MMPMID34845084
  • Jones CP; Ferre-D'Amare AR
  • RNA 2022[Feb]; 28 (2): 239-249 PMID34845084show ga
  • SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 A-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics.
  • |*Frameshifting, Ribosomal[MESH]
  • |*Nucleic Acid Conformation[MESH]
  • |Codon, Terminator[MESH]
  • |Crystallography, X-Ray[MESH]
  • |Models, Molecular[MESH]
  • |Mutation[MESH]
  • |RNA, Viral/*chemistry/genetics[MESH]
  • |SARS-CoV-2/*genetics[MESH]

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  • suck abstract from ncbi

    239 2.28 2022