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10.1002/eji.202149626 http://scihub22266oqcxt.onion/10.1002/eji.202149626 34837225!9015354!34837225     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34837225.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2022 ; 52 (3): 503-510 Nephropedia Template TP {{tp|p=34837225|t=2022. COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations |pdf=|usr=}}{{34837225}} gab.com Text COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34837225 #FOAvip Corona disease 2019 (COVID-19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID-19 severity. However, several questions pertain with respect to the metabolome in COVID-19. We performed an in-depth assessment of 1129 unique metabolites in 27 hospitalized COVID-19 patients and integrated results with large-scale proteomic and immunology data to capture multiorgan system perturbations. More than half of the detected metabolic alterations in COVID-19 were driven by patient-specific confounding factors ranging from comorbidities to xenobiotic substances. Systematically adjusting for this, a COVID-19-specific metabolic imprint was defined which, over time, underwent a switch in response to severe acute respiratory syndrome coronavirus-2 seroconversion. Integration of the COVID-19 metabolome with clinical, cellular, molecular, and immunological severity scales further revealed a network of metabolic trajectories aligned with multiple pathways for immune activation, and organ damage including neurological inflammation and damage. Altogether, this resource refines our understanding of the multiorgan system perturbations in severe COVID-19 patients. Twit Text FOAVip COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34837225 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34837225 #FOAvip English Wikipedia <ref>{{Cite pmid|34837225}}</ref> COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations #MMPMID34837225 Cornillet M; Strunz B; Rooyackers O; Ponzetta A; Chen P; Muvva JR; Akber M; Buggert M; Chambers BJ; Dzidic M; Filipovic I; Gorin JB; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Parrot T; Perez-Potti A; Rivera-Ballesteros O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Eriksson LI; Aleman S; Stralin K; Ljunggren HG; Bjorkstrom NK Eur J Immunol 2022[Mar]; 52 (3): 503-510 PMID34837225show ga Corona disease 2019 (COVID-19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID-19 severity. However, several questions pertain with respect to the metabolome in COVID-19. We performed an in-depth assessment of 1129 unique metabolites in 27 hospitalized COVID-19 patients and integrated results with large-scale proteomic and immunology data to capture multiorgan system perturbations. More than half of the detected metabolic alterations in COVID-19 were driven by patient-specific confounding factors ranging from comorbidities to xenobiotic substances. Systematically adjusting for this, a COVID-19-specific metabolic imprint was defined which, over time, underwent a switch in response to severe acute respiratory syndrome coronavirus-2 seroconversion. Integration of the COVID-19 metabolome with clinical, cellular, molecular, and immunological severity scales further revealed a network of metabolic trajectories aligned with multiple pathways for immune activation, and organ damage including neurological inflammation and damage. Altogether, this resource refines our understanding of the multiorgan system perturbations in severe COVID-19 patients. |*SARS-CoV-2[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |COVID-19/complications/*immunology/*metabolism[MESH] |Case-Control Studies[MESH] |Central Nervous System Diseases/etiology/immunology/metabolism[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Metabolome/*immunology[MESH] |Metabolomics[MESH] |Middle Aged[MESH] |Organ Specificity[MESH] |Pandemics[MESH] |Phenotype[MESH] |Proteomics[MESH] |Severity of Illness Index[MESH]COVID-19-specific metabolic imprint yields insights into multiorgan sy(epmc).pdf DeepDyve Pubget Overpricing