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10.3390/v13112306 http://scihub22266oqcxt.onion/10.3390/v13112306 34835112!8619434!34835112     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (11): ä Nephropedia Template TP {{tp|p=34835112|t=2021. Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment Step |pdf=|usr=}}{{34835112}} gab.com Text Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment Step JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34835112 #FOAvip Anti-viral small molecules are currently lacking for treating coronavirus infection. The long development timescales for such drugs are a major problem, but could be shortened by repurposing existing drugs. We therefore screened a small library of FDA-approved compounds for potential severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antivirals using a pseudovirus system that allows a sensitive read-out of infectivity. A group of structurally-related compounds, showing moderate inhibitory activity with IC(50) values in the 2-5 muM range, were identified. Further studies demonstrated that these "kite-shaped" molecules were surprisingly specific for SARS-CoV-1 and SARS-CoV-2 and that they acted early in the entry steps of the viral infectious cycle, but did not affect virus attachment to the cells. Moreover, the compounds were able to prevent infection in both kidney- and lung-derived human cell lines. The structural homology of the hits allowed the production of a well-defined pharmacophore that was found to be highly accurate in predicting the anti-viral activity of the compounds in the screen. We discuss the prospects of repurposing these existing drugs for treating current and future coronavirus outbreaks. Twit Text FOAVip Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment Step ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34835112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34835112 #FOAvip English Wikipedia <ref>{{Cite pmid|34835112}}</ref> Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment Step #MMPMID34835112 Chan SW; Shafi T; Ford RC Viruses 2021[Nov]; 13 (11): ä PMID34835112show ga Anti-viral small molecules are currently lacking for treating coronavirus infection. The long development timescales for such drugs are a major problem, but could be shortened by repurposing existing drugs. We therefore screened a small library of FDA-approved compounds for potential severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antivirals using a pseudovirus system that allows a sensitive read-out of infectivity. A group of structurally-related compounds, showing moderate inhibitory activity with IC(50) values in the 2-5 muM range, were identified. Further studies demonstrated that these "kite-shaped" molecules were surprisingly specific for SARS-CoV-1 and SARS-CoV-2 and that they acted early in the entry steps of the viral infectious cycle, but did not affect virus attachment to the cells. Moreover, the compounds were able to prevent infection in both kidney- and lung-derived human cell lines. The structural homology of the hits allowed the production of a well-defined pharmacophore that was found to be highly accurate in predicting the anti-viral activity of the compounds in the screen. We discuss the prospects of repurposing these existing drugs for treating current and future coronavirus outbreaks. |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19/*virology[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Drug Discovery/methods[MESH] |Drug Repositioning[MESH] |Drug Synergism[MESH] |Humans[MESH] |Leukemia Virus, Murine/*drug effects/metabolism[MESH] |Mice[MESH] |Molecular Docking Simulation[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH] |Vero Cells[MESH] |Virus Attachment/drug effects[MESH]Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment(epmc).pdf DeepDyve Pubget Overpricing