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10.3390/v13112212 http://scihub22266oqcxt.onion/10.3390/v13112212 34835019!8623150!34835019     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34835019.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Viruses 2021 ; 13 (11): ä Nephropedia Template TP {{tp|p=34835019|t=2021. Single-Cell RNAseq Profiling of Human gammadelta T Lymphocytes in Virus-Related Cancers and COVID-19 Disease |pdf=|usr=}}{{34835019}} gab.com Text Single-Cell RNAseq Profiling of Human gammadelta T Lymphocytes in Virus-Related Cancers and COVID-19 Disease JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34835019 #FOAvip The detailed characterization of human gammadelta T lymphocyte differentiation at the single-cell transcriptomic (scRNAseq) level in tumors and patients with coronavirus disease 2019 (COVID-19) requires both a reference differentiation trajectory of gammadelta T cells and a robust mapping method for additional gammadelta T lymphocytes. Here, we incepted such a method to characterize thousands of gammadelta T lymphocytes from (n = 95) patients with cancer or adult and pediatric COVID-19 disease. We found that cancer patients with human papillomavirus-positive head and neck squamous cell carcinoma and Epstein-Barr virus-positive Hodgkin's lymphoma have gammadelta tumor-infiltrating T lymphocytes that are more prone to recirculate from the tumor and avoid exhaustion. In COVID-19, both TCRVgamma9 and TCRVgammanon9 subsets of gammadelta T lymphocytes relocalize from peripheral blood mononuclear cells (PBMC) to the infected lung tissue, where their advanced differentiation, tissue residency, and exhaustion reflect T cell activation. Although severe COVID-19 disease increases both recruitment and exhaustion of gammadelta T lymphocytes in infected lung lesions but not blood, the anti-IL6R therapy with Tocilizumab promotes gammadelta T lymphocyte differentiation in patients with COVID-19. PBMC from pediatric patients with acute COVID-19 disease display similar gammadelta T cell lymphopenia to that seen in adult patients. However, blood gammadelta T cells from children with the COVID-19-related multisystem inflammatory syndrome are not lymphodepleted, but they are differentiated as in healthy PBMC. These findings suggest that some virus-induced memory gammadelta T lymphocytes durably persist in the blood of adults and could subsequently infiltrate and recirculate in tumors. Twit Text FOAVip Single-Cell RNAseq Profiling of Human gammadelta T Lymphocytes in Virus-Related Cancers and COVID-19 Disease ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34835019 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34835019 #FOAvip English Wikipedia <ref>{{Cite pmid|34835019}}</ref> Single-Cell RNAseq Profiling of Human gammadelta T Lymphocytes in Virus-Related Cancers and COVID-19 Disease #MMPMID34835019 Cerapio JP; Perrier M; Pont F; Tosolini M; Laurent C; Bertani S; Fournie JJ Viruses 2021[Nov]; 13 (11): ä PMID34835019show ga The detailed characterization of human gammadelta T lymphocyte differentiation at the single-cell transcriptomic (scRNAseq) level in tumors and patients with coronavirus disease 2019 (COVID-19) requires both a reference differentiation trajectory of gammadelta T cells and a robust mapping method for additional gammadelta T lymphocytes. Here, we incepted such a method to characterize thousands of gammadelta T lymphocytes from (n = 95) patients with cancer or adult and pediatric COVID-19 disease. We found that cancer patients with human papillomavirus-positive head and neck squamous cell carcinoma and Epstein-Barr virus-positive Hodgkin's lymphoma have gammadelta tumor-infiltrating T lymphocytes that are more prone to recirculate from the tumor and avoid exhaustion. In COVID-19, both TCRVgamma9 and TCRVgammanon9 subsets of gammadelta T lymphocytes relocalize from peripheral blood mononuclear cells (PBMC) to the infected lung tissue, where their advanced differentiation, tissue residency, and exhaustion reflect T cell activation. Although severe COVID-19 disease increases both recruitment and exhaustion of gammadelta T lymphocytes in infected lung lesions but not blood, the anti-IL6R therapy with Tocilizumab promotes gammadelta T lymphocyte differentiation in patients with COVID-19. PBMC from pediatric patients with acute COVID-19 disease display similar gammadelta T cell lymphopenia to that seen in adult patients. However, blood gammadelta T cells from children with the COVID-19-related multisystem inflammatory syndrome are not lymphodepleted, but they are differentiated as in healthy PBMC. These findings suggest that some virus-induced memory gammadelta T lymphocytes durably persist in the blood of adults and could subsequently infiltrate and recirculate in tumors. |*RNA-Seq[MESH] |Adult[MESH] |Bronchoalveolar Lavage Fluid/immunology[MESH] |COVID-19/complications/*immunology[MESH] |Cell Differentiation[MESH] |Child[MESH] |Head and Neck Neoplasms/immunology/virology[MESH] |Herpesvirus 4, Human/isolation & purification[MESH] |Hodgkin Disease/immunology/virology[MESH] |Humans[MESH] |Lung/immunology[MESH] |Lymphocyte Activation[MESH] |Lymphocyte Count[MESH] |Lymphocytes, Tumor-Infiltrating/*immunology/metabolism/physiology[MESH] |Neoplasms/*immunology/virology[MESH] |Papillomaviridae/isolation & purification[MESH] |Receptors, Antigen, T-Cell, gamma-delta/*immunology[MESH] |Severity of Illness Index[MESH] |Single-Cell Analysis[MESH] |Systemic Inflammatory Response Syndrome/immunology[MESH]Single-Cell RNAseq Profiling of Human gammadelta T Lymphocytes in Viru(epmc).pdf DeepDyve Pubget Overpricing