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10.3390/v13112212

http://scihub22266oqcxt.onion/10.3390/v13112212
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34835019!8623150!34835019
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suck abstract from ncbi


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pmid34835019      Viruses 2021 ; 13 (11): ä
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  • Single-Cell RNAseq Profiling of Human gammadelta T Lymphocytes in Virus-Related Cancers and COVID-19 Disease #MMPMID34835019
  • Cerapio JP; Perrier M; Pont F; Tosolini M; Laurent C; Bertani S; Fournie JJ
  • Viruses 2021[Nov]; 13 (11): ä PMID34835019show ga
  • The detailed characterization of human gammadelta T lymphocyte differentiation at the single-cell transcriptomic (scRNAseq) level in tumors and patients with coronavirus disease 2019 (COVID-19) requires both a reference differentiation trajectory of gammadelta T cells and a robust mapping method for additional gammadelta T lymphocytes. Here, we incepted such a method to characterize thousands of gammadelta T lymphocytes from (n = 95) patients with cancer or adult and pediatric COVID-19 disease. We found that cancer patients with human papillomavirus-positive head and neck squamous cell carcinoma and Epstein-Barr virus-positive Hodgkin's lymphoma have gammadelta tumor-infiltrating T lymphocytes that are more prone to recirculate from the tumor and avoid exhaustion. In COVID-19, both TCRVgamma9 and TCRVgammanon9 subsets of gammadelta T lymphocytes relocalize from peripheral blood mononuclear cells (PBMC) to the infected lung tissue, where their advanced differentiation, tissue residency, and exhaustion reflect T cell activation. Although severe COVID-19 disease increases both recruitment and exhaustion of gammadelta T lymphocytes in infected lung lesions but not blood, the anti-IL6R therapy with Tocilizumab promotes gammadelta T lymphocyte differentiation in patients with COVID-19. PBMC from pediatric patients with acute COVID-19 disease display similar gammadelta T cell lymphopenia to that seen in adult patients. However, blood gammadelta T cells from children with the COVID-19-related multisystem inflammatory syndrome are not lymphodepleted, but they are differentiated as in healthy PBMC. These findings suggest that some virus-induced memory gammadelta T lymphocytes durably persist in the blood of adults and could subsequently infiltrate and recirculate in tumors.
  • |*RNA-Seq[MESH]
  • |Adult[MESH]
  • |Bronchoalveolar Lavage Fluid/immunology[MESH]
  • |COVID-19/complications/*immunology[MESH]
  • |Cell Differentiation[MESH]
  • |Child[MESH]
  • |Head and Neck Neoplasms/immunology/virology[MESH]
  • |Herpesvirus 4, Human/isolation & purification[MESH]
  • |Hodgkin Disease/immunology/virology[MESH]
  • |Humans[MESH]
  • |Lung/immunology[MESH]
  • |Lymphocyte Activation[MESH]
  • |Lymphocyte Count[MESH]
  • |Lymphocytes, Tumor-Infiltrating/*immunology/metabolism/physiology[MESH]
  • |Neoplasms/*immunology/virology[MESH]
  • |Papillomaviridae/isolation & purification[MESH]
  • |Receptors, Antigen, T-Cell, gamma-delta/*immunology[MESH]
  • |Severity of Illness Index[MESH]
  • |Single-Cell Analysis[MESH]
  • |Systemic Inflammatory Response Syndrome/immunology[MESH]


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