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10.3390/cells10113047 http://scihub22266oqcxt.onion/10.3390/cells10113047 34831271!8618878!34831271     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2021 ; 10 (11): ä Nephropedia Template TP {{tp|p=34831271|t=2021. Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases |pdf=|usr=}}{{34831271}} gab.com Text Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=34831271 #FOAvip Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives inflammation in disease. Gal-3's role in the central nervous system has been less studied than in the immune system. However, recent studies show it exacerbates Alzheimer's disease and is upregulated in a large variety of brain injuries, while loss of Gal-3 function can diminish symptoms of neurodegenerative diseases such as Alzheimer's. Several novel molecular pathways for Gal-3 were recently uncovered. It is a natural ligand for TREM2 (triggering receptor expressed on myeloid cells), TLR4 (Toll-like receptor 4), and IR (insulin receptor). Gal-3 regulates a number of pathways including stimulation of bone morphogenetic protein (BMP) signaling and modulating Wnt signalling in a context-dependent manner. Gal-3 typically acts in pathology but is now known to affect subventricular zone (SVZ) neurogenesis and gliogenesis in the healthy brain. Despite its myriad interactors, Gal-3 has surprisingly specific and important functions in regulating SVZ neurogenesis in disease. Gal-1, a similar lectin often co-expressed with Gal-3, also has profound effects on brain pathology and adult neurogenesis. Remarkably, Gal-3's carbohydrate recognition domain bears structural similarity to the SARS-CoV-2 virus spike protein necessary for cell entry. Gal-3 can be targeted pharmacologically and is a valid target for several diseases involving brain inflammation. The wealth of molecular pathways now known further suggest its modulation could be therapeutically useful. Twit Text FOAVip Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=34831271 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34831271 #FOAvip English Wikipedia <ref>{{Cite pmid|34831271}}</ref> Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases #MMPMID34831271 Soares LC; Al-Dalahmah O; Hillis J; Young CC; Asbed I; Sakaguchi M; O'Neill E; Szele FG Cells 2021[Nov]; 10 (11): ä PMID34831271show ga Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives inflammation in disease. Gal-3's role in the central nervous system has been less studied than in the immune system. However, recent studies show it exacerbates Alzheimer's disease and is upregulated in a large variety of brain injuries, while loss of Gal-3 function can diminish symptoms of neurodegenerative diseases such as Alzheimer's. Several novel molecular pathways for Gal-3 were recently uncovered. It is a natural ligand for TREM2 (triggering receptor expressed on myeloid cells), TLR4 (Toll-like receptor 4), and IR (insulin receptor). Gal-3 regulates a number of pathways including stimulation of bone morphogenetic protein (BMP) signaling and modulating Wnt signalling in a context-dependent manner. Gal-3 typically acts in pathology but is now known to affect subventricular zone (SVZ) neurogenesis and gliogenesis in the healthy brain. Despite its myriad interactors, Gal-3 has surprisingly specific and important functions in regulating SVZ neurogenesis in disease. Gal-1, a similar lectin often co-expressed with Gal-3, also has profound effects on brain pathology and adult neurogenesis. Remarkably, Gal-3's carbohydrate recognition domain bears structural similarity to the SARS-CoV-2 virus spike protein necessary for cell entry. Gal-3 can be targeted pharmacologically and is a valid target for several diseases involving brain inflammation. The wealth of molecular pathways now known further suggest its modulation could be therapeutically useful. |*Neurogenesis[MESH] |Animals[MESH] |Brain/metabolism/pathology[MESH] |COVID-19/metabolism/pathology[MESH] |Cell Movement[MESH] |Galectin 3/chemistry/genetics/*metabolism[MESH] |Humans[MESH] |Inflammation[MESH] |Lateral Ventricles/cytology/growth & development/pathology[MESH] |Nervous System Diseases/metabolism/*pathology[MESH] |Neural Stem Cells/cytology[MESH]Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological (epmc).pdf DeepDyve Pubget Overpricing