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10.3390/cells10112953 http://scihub22266oqcxt.onion/10.3390/cells10112953 34831176!8616207!34831176     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2021 ; 10 (11): ä Nephropedia Template TP {{tp|p=34831176|t=2021. Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication |pdf=|usr=}}{{34831176}} gab.com Text Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=34831176 #FOAvip Human coronavirus (HCoV) similar to other viruses rely on host cell machinery for both replication and to spread. The p97/VCP ATPase is associated with diverse pathways that may favor HCoV replication. In this study, we assessed the role of p97 and associated host responses in human lung cell line H1299 after HCoV-229E or HCoV-OC43 infection. Inhibition of p97 function by small molecule inhibitors shows antiviral activity, particularly at early stages of the virus life cycle, during virus uncoating and viral RNA replication. Importantly, p97 activity inhibition protects human cells against HCoV-induced cytopathic effects. The p97 knockdown also inhibits viral production in infected cells. Unbiased quantitative proteomics analyses reveal that HCoV-OC43 infection resulted in proteome changes enriched in cellular senescence and DNA repair during virus replication. Further analysis of protein changes between infected cells with control and p97 shRNA identifies cell cycle pathways for both HCoV-229E and HCoV-OC43 infection. Together, our data indicate a role for the essential host protein p97 in supporting HCoV replication, suggesting that p97 is a therapeutic target to treat HCoV infection. Twit Text FOAVip Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=34831176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34831176 #FOAvip English Wikipedia <ref>{{Cite pmid|34831176}}</ref> Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication #MMPMID34831176 Cheng KW; Li S; Wang F; Ruiz-Lopez NM; Houerbi N; Chou TF Cells 2021[Oct]; 10 (11): ä PMID34831176show ga Human coronavirus (HCoV) similar to other viruses rely on host cell machinery for both replication and to spread. The p97/VCP ATPase is associated with diverse pathways that may favor HCoV replication. In this study, we assessed the role of p97 and associated host responses in human lung cell line H1299 after HCoV-229E or HCoV-OC43 infection. Inhibition of p97 function by small molecule inhibitors shows antiviral activity, particularly at early stages of the virus life cycle, during virus uncoating and viral RNA replication. Importantly, p97 activity inhibition protects human cells against HCoV-induced cytopathic effects. The p97 knockdown also inhibits viral production in infected cells. Unbiased quantitative proteomics analyses reveal that HCoV-OC43 infection resulted in proteome changes enriched in cellular senescence and DNA repair during virus replication. Further analysis of protein changes between infected cells with control and p97 shRNA identifies cell cycle pathways for both HCoV-229E and HCoV-OC43 infection. Together, our data indicate a role for the essential host protein p97 in supporting HCoV replication, suggesting that p97 is a therapeutic target to treat HCoV infection. |Antiviral Agents/pharmacology[MESH] |Cell Cycle/drug effects[MESH] |Cell Line[MESH] |Coronavirus 229E, Human/drug effects/*physiology[MESH] |Coronavirus OC43, Human/drug effects/*physiology[MESH] |Cytopathogenic Effect, Viral/drug effects[MESH] |Humans[MESH] |Proteome/drug effects/metabolism[MESH] |RNA, Small Interfering/genetics[MESH] |RNA, Viral/biosynthesis[MESH] |Valosin Containing Protein/antagonists & inhibitors/genetics/*metabolism[MESH] |Virus Replication/drug effects/*physiology[MESH]Impacts of p97 on Proteome Changes in Human Cells during Coronaviral R(epmc).pdf DeepDyve Pubget Overpricing