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10.3390/antibiotics10111364

http://scihub22266oqcxt.onion/10.3390/antibiotics10111364
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34827302!8615228!34827302
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suck abstract from ncbi


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pmid34827302      Antibiotics+(Basel) 2021 ; 10 (11): ä
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  • Correlation between Previous Antibiotic Exposure and COVID-19 Severity A Population-Based Cohort Study #MMPMID34827302
  • Llor C; Ouchi D; Giner-Soriano M; Garcia-Sangenis A; Bjerrum L; Morros R
  • Antibiotics (Basel) 2021[Nov]; 10 (11): ä PMID34827302show ga
  • We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04-1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14-1.26; 1.41; 95% CI: 1.36-1.46; and 1.35; 95% CI: 1.30-1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease.
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