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10.1126/sciadv.abl6096 http://scihub22266oqcxt.onion/10.1126/sciadv.abl6096 34826236!8626076!34826236     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2021 ; 7 (48): eabl6096 Nephropedia Template TP {{tp|p=34826236|t=2021. Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures |pdf=|usr=}}{{34826236}} gab.com Text Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34826236 #FOAvip The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication and to serve as leads for antiviral therapeutic development. Here, we report on the identification of amiloride-based small molecules that potently inhibit OC43 and SARS-CoV-2 replication through targeting of conserved structured elements within the viral 5'-end. Nuclear magnetic resonance-based structural studies revealed specific amiloride interactions with stem loops containing bulge like structures and were predicted to be strongly bound by the lead amilorides in retrospective docking studies. Amilorides represent the first antiviral small molecules that target RNA structures within the 5' untranslated regions and proximal region of the CoV genomes. These molecules will serve as chemical probes to further understand CoV RNA biology and can pave the way for the development of specific CoV RNA-targeted antivirals. Twit Text FOAVip Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34826236 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34826236 #FOAvip English Wikipedia <ref>{{Cite pmid|34826236}}</ref> Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures #MMPMID34826236 Zafferani M; Haddad C; Luo L; Davila-Calderon J; Chiu LY; Mugisha CS; Monaghan AG; Kennedy AA; Yesselman JD; Gifford RJ; Tai AW; Kutluay SB; Li ML; Brewer G; Tolbert BS; Hargrove AE Sci Adv 2021[Nov]; 7 (48): eabl6096 PMID34826236show ga The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication and to serve as leads for antiviral therapeutic development. Here, we report on the identification of amiloride-based small molecules that potently inhibit OC43 and SARS-CoV-2 replication through targeting of conserved structured elements within the viral 5'-end. Nuclear magnetic resonance-based structural studies revealed specific amiloride interactions with stem loops containing bulge like structures and were predicted to be strongly bound by the lead amilorides in retrospective docking studies. Amilorides represent the first antiviral small molecules that target RNA structures within the 5' untranslated regions and proximal region of the CoV genomes. These molecules will serve as chemical probes to further understand CoV RNA biology and can pave the way for the development of specific CoV RNA-targeted antivirals. äAmilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA st(epmc).pdf DeepDyve Pubget Overpricing