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10.1038/s41580-021-00432-z http://scihub22266oqcxt.onion/10.1038/s41580-021-00432-z 34824452!8613731!34824452     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Mol+Cell+Biol 2022 ; 23 (1): 21-39 Nephropedia Template TP {{tp|p=34824452|t=2022. Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design |pdf=|usr=}}{{34824452}} gab.com Text Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34824452 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of people and continues to cause massive global upheaval. Coronaviruses are positive-strand RNA viruses with an unusually large genome of ~30 kb. They express an RNA-dependent RNA polymerase and a cohort of other replication enzymes and supporting factors to transcribe and replicate their genomes. The proteins performing these essential processes are prime antiviral drug targets, but drug discovery is hindered by our incomplete understanding of coronavirus RNA synthesis and processing. In infected cells, the RNA-dependent RNA polymerase must coordinate with other viral and host factors to produce both viral mRNAs and new genomes. Recent research aiming to decipher and contextualize the structures, functions and interplay of the subunits of the SARS-CoV-2 replication and transcription complex proteins has burgeoned. In this Review, we discuss recent advancements in our understanding of the molecular basis and complexity of the coronavirus RNA-synthesizing machinery. Specifically, we outline the mechanisms and regulation of RNA translation, replication and transcription. We also discuss the composition of the replication and transcription complexes and their suitability as targets for antiviral therapy. Twit Text FOAVip Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34824452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34824452 #FOAvip English Wikipedia <ref>{{Cite pmid|34824452}}</ref> Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design #MMPMID34824452 Malone B; Urakova N; Snijder EJ; Campbell EA Nat Rev Mol Cell Biol 2022[Jan]; 23 (1): 21-39 PMID34824452show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of people and continues to cause massive global upheaval. Coronaviruses are positive-strand RNA viruses with an unusually large genome of ~30 kb. They express an RNA-dependent RNA polymerase and a cohort of other replication enzymes and supporting factors to transcribe and replicate their genomes. The proteins performing these essential processes are prime antiviral drug targets, but drug discovery is hindered by our incomplete understanding of coronavirus RNA synthesis and processing. In infected cells, the RNA-dependent RNA polymerase must coordinate with other viral and host factors to produce both viral mRNAs and new genomes. Recent research aiming to decipher and contextualize the structures, functions and interplay of the subunits of the SARS-CoV-2 replication and transcription complex proteins has burgeoned. In this Review, we discuss recent advancements in our understanding of the molecular basis and complexity of the coronavirus RNA-synthesizing machinery. Specifically, we outline the mechanisms and regulation of RNA translation, replication and transcription. We also discuss the composition of the replication and transcription complexes and their suitability as targets for antiviral therapy. |*Drug Design[MESH] |*Transcription, Genetic/drug effects[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Humans[MESH] |RNA, Viral/metabolism[MESH] |SARS-CoV-2/*genetics/*physiology[MESH]Structures and functions of coronavirus replication-transcription comp(epmc).pdf DeepDyve Pubget Overpricing