Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-021-02119-z http://scihub22266oqcxt.onion/10.1038/s41598-021-02119-z 34824310!8617276!34824310     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 22913 Nephropedia Template TP {{tp|p=34824310|t=2021. A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19 |pdf=|usr=}}{{34824310}} gab.com Text A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34824310 #FOAvip Inflammation is a physiological process whose deregulation causes some diseases including cancer. Nuclear Factor kB (NF-kB) is a family of ubiquitous and inducible transcription factors, in which the p65/p50 heterodimer is the most abundant complex, that play critical roles mainly in inflammation. Glucocorticoid Receptor (GR) is a ligand-activated transcription factor and acts as an anti-inflammatory agent and immunosuppressant. Thus, NF-kB and GR are physiological antagonists in the inflammation process. Here we show that in mice and humans there is a spliced variant of p65, named p65 iso5, which binds the corticosteroid hormone dexamethasone amplifying the effect of the glucocorticoid receptor and is expressed in the liver of patients with hepatic cirrhosis and hepatocellular carcinoma (HCC). Furthermore, we have quantified the gene expression level of p65 and p65 iso5 in the PBMC of patients affected by SARS-CoV-2 disease. The results showed that in these patients the p65 and p65 iso5 mRNA levels are higher than in healthy subjects. The ability of p65 iso5 to bind dexamethasone and the regulation of the glucocorticoid (GC) response in the opposite way of the wild type improves our knowledge and understanding of the anti-inflammatory response and identifies it as a new therapeutic target to control inflammation and related diseases. Twit Text FOAVip A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34824310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34824310 #FOAvip English Wikipedia <ref>{{Cite pmid|34824310}}</ref> A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19 #MMPMID34824310 Spinelli G; Biddeci G; Artale A; Valentino F; Tarantino G; Gallo G; Gianguzza F; Conaldi PG; Corrao S; Gervasi F; Aronica TS; Di Leonardo A; Duro G; Di Blasi F Sci Rep 2021[Nov]; 11 (1): 22913 PMID34824310show ga Inflammation is a physiological process whose deregulation causes some diseases including cancer. Nuclear Factor kB (NF-kB) is a family of ubiquitous and inducible transcription factors, in which the p65/p50 heterodimer is the most abundant complex, that play critical roles mainly in inflammation. Glucocorticoid Receptor (GR) is a ligand-activated transcription factor and acts as an anti-inflammatory agent and immunosuppressant. Thus, NF-kB and GR are physiological antagonists in the inflammation process. Here we show that in mice and humans there is a spliced variant of p65, named p65 iso5, which binds the corticosteroid hormone dexamethasone amplifying the effect of the glucocorticoid receptor and is expressed in the liver of patients with hepatic cirrhosis and hepatocellular carcinoma (HCC). Furthermore, we have quantified the gene expression level of p65 and p65 iso5 in the PBMC of patients affected by SARS-CoV-2 disease. The results showed that in these patients the p65 and p65 iso5 mRNA levels are higher than in healthy subjects. The ability of p65 iso5 to bind dexamethasone and the regulation of the glucocorticoid (GC) response in the opposite way of the wild type improves our knowledge and understanding of the anti-inflammatory response and identifies it as a new therapeutic target to control inflammation and related diseases. |Adrenal Cortex Hormones/metabolism[MESH] |Adult[MESH] |Alternative Splicing[MESH] |Animals[MESH] |COVID-19/immunology[MESH] |Carcinoma, Hepatocellular/metabolism[MESH] |Dexamethasone/metabolism[MESH] |Female[MESH] |Gene Expression Regulation/genetics[MESH] |Gene Expression/genetics[MESH] |Glucocorticoids/metabolism[MESH] |Hepatitis/metabolism[MESH] |Humans[MESH] |Inflammation/*immunology/metabolism[MESH] |Leukocytes, Mononuclear/metabolism[MESH] |Liver Diseases/immunology[MESH] |Liver Neoplasms/metabolism[MESH] |Liver/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Middle Aged[MESH] |NF-kappa B/metabolism[MESH] |Protein Isoforms[MESH] |Receptors, Glucocorticoid/immunology/*metabolism[MESH] |SARS-CoV-2/pathogenicity[MESH]A new p65 isoform that bind the glucocorticoid hormone and is expresse(epmc).pdf DeepDyve Pubget Overpricing