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10.1017/erm.2021.21 http://scihub22266oqcxt.onion/10.1017/erm.2021.21 34823627!ä!34823627 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34823627.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Expert+Rev+Mol+Med 2021 ; 23 (ä): e18 Nephropedia Template TP {{tp|p=34823627|t=2021. Alveolar macrophages: novel therapeutic targets for respiratory diseases |pdf=|usr=}}{{34823627}} gab.com Text Alveolar macrophages: novel therapeutic targets for respiratory diseases JO: Expert Rev Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34823627 #FOAvip Alveolar macrophages (AMs) are lung-resident myeloid cells that sit at the interface of the airway and lung tissue. Under homeostatic conditions, their primary function is to clear debris, dead cells and excess surfactant from the airways. They also serve as innate pulmonary sentinels for respiratory pathogens and environmental airborne particles and as regulators of pulmonary inflammation. However, they have not typically been viewed as primary therapeutic targets for respiratory diseases. Here, we discuss the role of AMs in various lung diseases, explore the potential therapeutic strategies to target these innate cells and weigh the potential risks and challenges of such therapies. Additionally, in the context of the COVID-19 pandemic, we examine the role AMs play in severe disease and the therapeutic strategies that have been harnessed to modulate their function and protect against severe lung damage. There are many novel approaches in development to target AMs, such as inhaled antibiotics, liposomal and microparticle delivery systems, and host-directed therapies, which have the potential to provide critical treatment to patients suffering from severe respiratory diseases, yet there is still much work to be done to fully understand the possible benefits and risks of such approaches. Twit Text FOAVip Alveolar macrophages: novel therapeutic targets for respiratory diseases ????Expert Rev Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34823627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34823627 #FOAvip English Wikipedia <ref>{{Cite pmid|34823627}}</ref> Alveolar macrophages: novel therapeutic targets for respiratory diseases #MMPMID34823627 Lim PN; Cervantes MM; Pham LK; Rothchild AC Expert Rev Mol Med 2021[Nov]; 23 (ä): e18 PMID34823627show ga Alveolar macrophages (AMs) are lung-resident myeloid cells that sit at the interface of the airway and lung tissue. Under homeostatic conditions, their primary function is to clear debris, dead cells and excess surfactant from the airways. They also serve as innate pulmonary sentinels for respiratory pathogens and environmental airborne particles and as regulators of pulmonary inflammation. However, they have not typically been viewed as primary therapeutic targets for respiratory diseases. Here, we discuss the role of AMs in various lung diseases, explore the potential therapeutic strategies to target these innate cells and weigh the potential risks and challenges of such therapies. Additionally, in the context of the COVID-19 pandemic, we examine the role AMs play in severe disease and the therapeutic strategies that have been harnessed to modulate their function and protect against severe lung damage. There are many novel approaches in development to target AMs, such as inhaled antibiotics, liposomal and microparticle delivery systems, and host-directed therapies, which have the potential to provide critical treatment to patients suffering from severe respiratory diseases, yet there is still much work to be done to fully understand the possible benefits and risks of such approaches. |*COVID-19[MESH] |*Macrophages, Alveolar[MESH] |Humans[MESH] |Lung[MESH] |Pandemics[MESH]Alveolar macrophages: novel therapeutic targets for respiratory diseas(epmc).pdf DeepDyve Pubget Overpricing