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Are COVID-19 Vaccine Boosters Needed? The Science behind Boosters #MMPMID34817198
Burckhardt RM; Dennehy JJ; Poon LLM; Saif LJ; Enquist LW
J Virol 2022[Feb]; 96 (3): e0197321 PMID34817198show ga
Waning vaccine-induced immunity coupled with the emergence of SARS-CoV-2 variants has led to increases in breakthrough infections, prompting consideration for vaccine booster doses. Boosters have been reported to be safe and increase SARS-CoV-2-specific neutralizing antibody levels, but how these doses impact the trajectory of the global pandemic and herd immunity is unknown. Information on immunology, epidemiology, and equitable vaccine distribution should be considered when deciding the timing and eligibility for COVID-19 vaccine boosters.