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10.1016/j.smim.2021.101522 http://scihub22266oqcxt.onion/10.1016/j.smim.2021.101522 34815163!8576141!34815163     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semin+Immunol 2021 ; 55 (ä): 101522 Nephropedia Template TP {{tp|p=34815163|t=2021. Impaired innate antiviral defenses in COVID-19: Causes, consequences and therapeutic opportunities |pdf=|usr=}}{{34815163}} gab.com Text Impaired innate antiviral defenses in COVID-19: Causes, consequences and therapeutic opportunities JO: Semin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34815163 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged pathogen that has caused coronavirus disease 2019 (COVID-19), the worst pandemic of our times leading to tremendous loss of human life and unprecedented measures of social distancing. COVID-19 symptom manifestations range from asymptomatic disease to severe and lethal outcomes. Lack of previous exposure and immunity to SARS-CoV-2, and high infectivity of the virus have contributed to its broad spread across the globe. In the absence of specific adaptive immunity, innate immune mechanisms are crucial for efficient antiviral defenses and control of the infection. Accumulating evidence now suggests that the remarkable heterogeneity in COVID-19 disease manifestations is due to variable degrees of impairment of innate immune mechanisms. In this review, we summarize recent findings describing both viral and host intrinsic factors that have been linked to defective innate immune responses and account for severe COVID-19. We also discuss emerging therapeutic opportunities for targeting innate immunity for the treatment of COVID-19. Twit Text FOAVip Impaired innate antiviral defenses in COVID-19: Causes, consequences and therapeutic opportunities ????Semin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34815163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34815163 #FOAvip English Wikipedia <ref>{{Cite pmid|34815163}}</ref> Impaired innate antiviral defenses in COVID-19: Causes, consequences and therapeutic opportunities #MMPMID34815163 Galani IE; Andreakos E Semin Immunol 2021[Jun]; 55 (ä): 101522 PMID34815163show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged pathogen that has caused coronavirus disease 2019 (COVID-19), the worst pandemic of our times leading to tremendous loss of human life and unprecedented measures of social distancing. COVID-19 symptom manifestations range from asymptomatic disease to severe and lethal outcomes. Lack of previous exposure and immunity to SARS-CoV-2, and high infectivity of the virus have contributed to its broad spread across the globe. In the absence of specific adaptive immunity, innate immune mechanisms are crucial for efficient antiviral defenses and control of the infection. Accumulating evidence now suggests that the remarkable heterogeneity in COVID-19 disease manifestations is due to variable degrees of impairment of innate immune mechanisms. In this review, we summarize recent findings describing both viral and host intrinsic factors that have been linked to defective innate immune responses and account for severe COVID-19. We also discuss emerging therapeutic opportunities for targeting innate immunity for the treatment of COVID-19. |*COVID-19[MESH] |Adaptive Immunity[MESH] |Antiviral Agents/therapeutic use[MESH] |Humans[MESH] |Immunity, Innate[MESH]Impaired innate antiviral defenses in COVID-19: Causes, consequences a(epmc).pdf DeepDyve Pubget Overpricing