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10.1016/j.molcel.2021.10.027 http://scihub22266oqcxt.onion/10.1016/j.molcel.2021.10.027 34813758!ä!34813758 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34813758.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2022 ; 82 (1): 15-29 Nephropedia Template TP {{tp|p=34813758|t=2022. Deubiquitinases: From mechanisms to their inhibition by small molecules |pdf=|usr=}}{{34813758}} gab.com Text Deubiquitinases: From mechanisms to their inhibition by small molecules JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=34813758 #FOAvip Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in eukaryotic biology. Dysregulation of DUBs is implicated in several human diseases, highlighting the importance of DUB function. In addition, many pathogenic bacteria and viruses encode and deploy DUBs to manipulate host immune responses and establish infectious diseases in humans and animals. Hence, therapeutic targeting of DUBs is an increasingly explored area that requires an in-depth mechanistic understanding of human and pathogenic DUBs. In this review, we summarize the multiple layers of regulation that control autoinhibition, activation, and substrate specificity of DUBs. We discuss different strategies to inhibit DUBs and the progress in developing selective small-molecule DUB inhibitors. Finally, we propose a classification system of DUB inhibitors based on their mode of action. Twit Text FOAVip Deubiquitinases: From mechanisms to their inhibition by small molecules ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=34813758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34813758 #FOAvip English Wikipedia <ref>{{Cite pmid|34813758}}</ref> Deubiquitinases: From mechanisms to their inhibition by small molecules #MMPMID34813758 Lange SM; Armstrong LA; Kulathu Y Mol Cell 2022[Jan]; 82 (1): 15-29 PMID34813758show ga Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in eukaryotic biology. Dysregulation of DUBs is implicated in several human diseases, highlighting the importance of DUB function. In addition, many pathogenic bacteria and viruses encode and deploy DUBs to manipulate host immune responses and establish infectious diseases in humans and animals. Hence, therapeutic targeting of DUBs is an increasingly explored area that requires an in-depth mechanistic understanding of human and pathogenic DUBs. In this review, we summarize the multiple layers of regulation that control autoinhibition, activation, and substrate specificity of DUBs. We discuss different strategies to inhibit DUBs and the progress in developing selective small-molecule DUB inhibitors. Finally, we propose a classification system of DUB inhibitors based on their mode of action. |*COVID-19 Drug Treatment[MESH] |*COVID-19/enzymology[MESH] |*Deubiquitinating Enzymes/antagonists & inhibitors/metabolism[MESH] |*SARS-CoV-2[MESH] |Enzyme Inhibitors/*therapeutic use[MESH] |Humans[MESH]Deubiquitinases: From mechanisms to their inhibition by small molecule(epmc).pdf DeepDyve Pubget Overpricing