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10.1371/journal.pone.0260451 http://scihub22266oqcxt.onion/10.1371/journal.pone.0260451 34813629!8610263!34813629     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (11): e0260451 Nephropedia Template TP {{tp|p=34813629|t=2021. Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate |pdf=|usr=}}{{34813629}} gab.com Text Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34813629 #FOAvip The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing data of 16S rRNA V3-V5 regions of gut microbiota in 953 healthy subjects in ten countries were obtained from the public database. We made a generalized linear model (GLM) to predict the COVID-19 mortality rates using gut microbiota. GLM revealed that low genus Collinsella predicted high COVID-19 mortality rates with a markedly low p-value. Unsupervised clustering of gut microbiota in 953 subjects yielded five enterotypes. The mortality rates were increased from enterotypes 1 to 5, whereas the abundances of Collinsella were decreased from enterotypes 1 to 5 except for enterotype 2. Collinsella produces ursodeoxycholate. Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-alpha, IL-1beta, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome. Ursodeoxycholate produced by Collinsella may prevent COVID-19 infection and ameliorate acute respiratory distress syndrome in COVID-19 by suppressing cytokine storm syndrome. Twit Text FOAVip Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34813629 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34813629 #FOAvip English Wikipedia <ref>{{Cite pmid|34813629}}</ref> Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate #MMPMID34813629 Hirayama M; Nishiwaki H; Hamaguchi T; Ito M; Ueyama J; Maeda T; Kashihara K; Tsuboi Y; Ohno K PLoS One 2021[]; 16 (11): e0260451 PMID34813629show ga The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing data of 16S rRNA V3-V5 regions of gut microbiota in 953 healthy subjects in ten countries were obtained from the public database. We made a generalized linear model (GLM) to predict the COVID-19 mortality rates using gut microbiota. GLM revealed that low genus Collinsella predicted high COVID-19 mortality rates with a markedly low p-value. Unsupervised clustering of gut microbiota in 953 subjects yielded five enterotypes. The mortality rates were increased from enterotypes 1 to 5, whereas the abundances of Collinsella were decreased from enterotypes 1 to 5 except for enterotype 2. Collinsella produces ursodeoxycholate. Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-alpha, IL-1beta, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome. Ursodeoxycholate produced by Collinsella may prevent COVID-19 infection and ameliorate acute respiratory distress syndrome in COVID-19 by suppressing cytokine storm syndrome. |*Gastrointestinal Microbiome[MESH] |Actinobacteria/*physiology[MESH] |COVID-19/etiology/pathology/*prevention & control[MESH] |Humans[MESH] |Intestines/*microbiology[MESH] |SARS-CoV-2/*physiology[MESH]Intestinal Collinsella may mitigate infection and exacerbation of COVI(epmc).pdf DeepDyve Pubget Overpricing