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10.3389/fimmu.2021.777103

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.777103
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suck abstract from ncbi


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pmid34804068      Front+Immunol 2021 ; 12 (ä): 777103
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  • COVID-19 mRNA Vaccination in Lactation: Assessment of Adverse Events and Vaccine Related Antibodies in Mother-Infant Dyads #MMPMID34804068
  • Golan Y; Prahl M; Cassidy AG; Gay C; Wu AHB; Jigmeddagva U; Lin CY; Gonzalez VJ; Basilio E; Chidboy MA; Warrier L; Buarpung S; Li L; Murtha AP; Asiodu IV; Ahituv N; Flaherman VJ; Gaw SL
  • Front Immunol 2021[]; 12 (ä): 777103 PMID34804068show ga
  • BACKGROUND: Data regarding symptoms in the lactating mother-infant dyad and their immune response to COVID-19 mRNA vaccination during lactation are needed to inform vaccination guidelines. METHODS: From a prospective cohort of 50 lactating individuals who received mRNA-based vaccines for COVID-19 (mRNA-1273 and BNT162b2), blood and milk samples were collected prior to first vaccination dose, immediately prior to 2nd dose, and 4-10 weeks after 2nd dose. Symptoms in mother and infant were assessed by detailed questionnaires. Anti-SARS-CoV-2 antibody levels in blood and milk were measured by Pylon 3D automated immunoassay and ELISA. In addition, vaccine-related PEGylated proteins in milk were measured by ELISA. Blood samples were collected from a subset of infants whose mothers received the vaccine during lactation (4-15 weeks after mothers' 2nd dose). RESULTS: No severe maternal or infant adverse events were reported in this cohort. Two mothers and two infants were diagnosed with COVID-19 during the study period before achieving full immune response. PEGylated proteins were not found at significant levels in milk after vaccination. After vaccination, levels of anti-SARS-CoV-2 IgG and IgM significantly increased in maternal plasma and there was significant transfer of anti-SARS-CoV-2-Receptor Binding Domain (anti-RBD) IgA and IgG antibodies to milk. Milk IgA levels after the 2nd dose were negatively associated with infant age. Anti-SARS-CoV-2 IgG antibodies were not detected in the plasma of infants whose mothers were vaccinated during lactation. CONCLUSIONS: COVID-19 mRNA vaccines generate robust immune responses in plasma and milk of lactating individuals without severe adverse events reported.
  • |2019-nCoV Vaccine mRNA-1273[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/blood/*immunology[MESH]
  • |BNT162 Vaccine[MESH]
  • |COVID-19 Vaccines/*administration & dosage[MESH]
  • |COVID-19/prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin A/immunology[MESH]
  • |Immunoglobulin G/blood/immunology[MESH]
  • |Immunoglobulin M/blood/immunology[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Lactation/*immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Milk, Human/*immunology[MESH]


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