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10.1016/j.jacl.2021.10.005

http://scihub22266oqcxt.onion/10.1016/j.jacl.2021.10.005
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suck abstract from ncbi


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pmid34802985      J+Clin+Lipidol 2021 ; 15 (6): 796-804
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  • HDL proteome remodeling associates with COVID-19 severity #MMPMID34802985
  • Souza Junior DR; Silva ARM; Rosa-Fernandes L; Reis LR; Alexandria G; Bhosale SD; Ghilardi FR; Dalcoquio TF; Bertolin AJ; Nicolau JC; Marinho CRF; Wrenger C; Larsen MR; Siciliano RF; Di Mascio P; Palmisano G; Ronsein GE
  • J Clin Lipidol 2021[Nov]; 15 (6): 796-804 PMID34802985show ga
  • BACKGROUND: Besides the well-accepted role in lipid metabolism, high-density lipoprotein (HDL) also seems to participate in host immune response against infectious diseases. OBJECTIVE: We used a quantitative proteomic approach to test the hypothesis that alterations in HDL proteome associate with severity of Coronavirus disease 2019 (COVID-19). METHODS: Based on clinical criteria, subjects (n=41) diagnosed with COVID-19 were divided into two groups: a group of subjects presenting mild symptoms and a second group displaying severe symptoms and requiring hospitalization. Using a proteomic approach, we quantified the levels of 29 proteins in HDL particles derived from these subjects. RESULTS: We showed that the levels of serum amyloid A 1 and 2 (SAA1 and SAA2, respectively), pulmonary surfactant-associated protein B (SFTPB), apolipoprotein F (APOF), and inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) were increased by more than 50% in hospitalized patients, independently of sex, HDL-C or triglycerides when comparing with subjects presenting only mild symptoms. Altered HDL proteins were able to classify COVID-19 subjects according to the severity of the disease (error rate 4.9%). Moreover, apolipoprotein M (APOM) in HDL was inversely associated with odds of death due to COVID-19 complications (odds ratio [OR] per 1-SD increase in APOM was 0.27, with 95% confidence interval [CI] of 0.07 to 0.72, P=0.007). CONCLUSION: Our results point to a profound inflammatory remodeling of HDL proteome tracking with severity of COVID-19 infection. They also raise the possibility that HDL particles could play an important role in infectious diseases.
  • |Adult[MESH]
  • |Apolipoproteins/blood[MESH]
  • |COVID-19/*blood/*pathology[MESH]
  • |Cholesterol, HDL/blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lipoproteins, HDL/*blood[MESH]
  • |Male[MESH]
  • |Mass Spectrometry[MESH]
  • |Middle Aged[MESH]
  • |Proteomics[MESH]
  • |Serum Amyloid A Protein/metabolism[MESH]


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