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10.1016/j.biopha.2021.112420 http://scihub22266oqcxt.onion/10.1016/j.biopha.2021.112420 34801852!8585639!34801852     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2022 ; 145 (ä): 112420 Nephropedia Template TP {{tp|p=34801852|t=2022. Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets |pdf=|usr=}}{{34801852}} gab.com Text Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=34801852 #FOAvip Deciphering the molecular downstream consequences of severe acute respiratory syndrome coronavirus (SARS-CoV)- 2 infection is important for a greater understanding of the disease and treatment planning. Furthermore, greater understanding of the underlying mechanisms of diagnostic and therapeutic strategies can help in the development of vaccines and drugs against COVID-19. At present, the molecular mechanisms of SARS-CoV-2 in the host cells are not sufficiently comprehended. Some of the mechanisms are proposed considering the existing similarities between SARS-CoV-2 and the other members of the beta-CoVs, and others are explained based on studies advanced in the structure and function of SARS-CoV-2. In this review, we endeavored to map the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in vitro, in vivo and human observations, as well as existing suggestions. We addressed the specific signaling events that can cause cytokine storm and demonstrated three forms of cell death signaling following virus infection, including apoptosis, pyroptosis, and necroptosis. Given the elicited signaling pathways, we introduced possible pathway-based therapeutic targets; ADAM17 was especially highlighted as one of the most important elements of several signaling pathways involved in the immunopathogenesis of COVID-19. We also provided the possible drug candidates against these targets. Moreover, the cytokine-cytokine receptor interaction pathway was found as one of the important cross-talk pathways through a pathway-pathway interaction analysis for SARS-CoV-2 infection. Twit Text FOAVip Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=34801852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34801852 #FOAvip English Wikipedia <ref>{{Cite pmid|34801852}}</ref> Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets #MMPMID34801852 Farahani M; Niknam Z; Mohammadi Amirabad L; Amiri-Dashatan N; Koushki M; Nemati M; Danesh Pouya F; Rezaei-Tavirani M; Rasmi Y; Tayebi L Biomed Pharmacother 2022[Jan]; 145 (ä): 112420 PMID34801852show ga Deciphering the molecular downstream consequences of severe acute respiratory syndrome coronavirus (SARS-CoV)- 2 infection is important for a greater understanding of the disease and treatment planning. Furthermore, greater understanding of the underlying mechanisms of diagnostic and therapeutic strategies can help in the development of vaccines and drugs against COVID-19. At present, the molecular mechanisms of SARS-CoV-2 in the host cells are not sufficiently comprehended. Some of the mechanisms are proposed considering the existing similarities between SARS-CoV-2 and the other members of the beta-CoVs, and others are explained based on studies advanced in the structure and function of SARS-CoV-2. In this review, we endeavored to map the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in vitro, in vivo and human observations, as well as existing suggestions. We addressed the specific signaling events that can cause cytokine storm and demonstrated three forms of cell death signaling following virus infection, including apoptosis, pyroptosis, and necroptosis. Given the elicited signaling pathways, we introduced possible pathway-based therapeutic targets; ADAM17 was especially highlighted as one of the most important elements of several signaling pathways involved in the immunopathogenesis of COVID-19. We also provided the possible drug candidates against these targets. Moreover, the cytokine-cytokine receptor interaction pathway was found as one of the important cross-talk pathways through a pathway-pathway interaction analysis for SARS-CoV-2 infection. |*COVID-19 Drug Treatment[MESH] |*COVID-19/immunology/virology[MESH] |*Host-Pathogen Interactions/drug effects/immunology[MESH] |Drug Discovery[MESH] |Humans[MESH] |Molecular Targeted Therapy/*methods[MESH] |SARS-CoV-2/*physiology[MESH]Molecular pathways involved in COVID-19 and potential pathway-based th(epmc).pdf DeepDyve Pubget Overpricing