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10.1038/s41467-021-26498-z http://scihub22266oqcxt.onion/10.1038/s41467-021-26498-z 34799561!8605023!34799561     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 6761 Nephropedia Template TP {{tp|p=34799561|t=2021. Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities |pdf=|usr=}}{{34799561}} gab.com Text Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34799561 #FOAvip Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, most current large-scale methods do not identify this important class of protein-protein interactions. Uncovering peptide mediated interactions provides both a molecular understanding of viral interactions with their host and the foundation for developing novel antiviral reagents. Here we describe a viral peptide discovery approach covering 23 coronavirus strains that provides high resolution information on direct virus-host interactions. We identify 269 peptide-based interactions for 18 coronaviruses including a specific interaction between the human G3BP1/2 proteins and an PhixFG peptide motif in the SARS-CoV-2 nucleocapsid (N) protein. This interaction supports viral replication and through its PhixFG motif N rewires the G3BP1/2 interactome to disrupt stress granules. A peptide-based inhibitor disrupting the G3BP1/2-N interaction dampened SARS-CoV-2 infection showing that our results can be directly translated into novel specific antiviral reagents. Twit Text FOAVip Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34799561 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34799561 #FOAvip English Wikipedia <ref>{{Cite pmid|34799561}}</ref> Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities #MMPMID34799561 Kruse T; Benz C; Garvanska DH; Lindqvist R; Mihalic F; Coscia F; Inturi R; Sayadi A; Simonetti L; Nilsson E; Ali M; Kliche J; Moliner Morro A; Mund A; Andersson E; McInerney G; Mann M; Jemth P; Davey NE; Overby AK; Nilsson J; Ivarsson Y Nat Commun 2021[Nov]; 12 (1): 6761 PMID34799561show ga Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, most current large-scale methods do not identify this important class of protein-protein interactions. Uncovering peptide mediated interactions provides both a molecular understanding of viral interactions with their host and the foundation for developing novel antiviral reagents. Here we describe a viral peptide discovery approach covering 23 coronavirus strains that provides high resolution information on direct virus-host interactions. We identify 269 peptide-based interactions for 18 coronaviruses including a specific interaction between the human G3BP1/2 proteins and an PhixFG peptide motif in the SARS-CoV-2 nucleocapsid (N) protein. This interaction supports viral replication and through its PhixFG motif N rewires the G3BP1/2 interactome to disrupt stress granules. A peptide-based inhibitor disrupting the G3BP1/2-N interaction dampened SARS-CoV-2 infection showing that our results can be directly translated into novel specific antiviral reagents. |Adaptor Proteins, Signal Transducing/metabolism[MESH] |DNA Helicases/metabolism[MESH] |Humans[MESH] |Integration Host Factors/*metabolism[MESH] |Poly-ADP-Ribose Binding Proteins/metabolism[MESH] |RNA Helicases/metabolism[MESH] |RNA Recognition Motif Proteins/metabolism[MESH] |RNA-Binding Proteins/metabolism[MESH] |SARS-CoV-2/*metabolism[MESH]Large scale discovery of coronavirus-host factor protein interaction m(epmc).pdf DeepDyve Pubget Overpricing