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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Biochem+Sci 2022 ; 47 (2): 117-123 Nephropedia Template TP
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Contributions of single-particle cryoelectron microscopy toward fighting COVID-19 #MMPMID34799235
Rapp M; Shapiro L; Frank J
Trends Biochem Sci 2022[Feb]; 47 (2): 117-123 PMID34799235show ga
Single-particle cryoelectron microscopy (cryo-EM), whose full capabilities have been realized only within the past decade, has had a pivotal role in the fight against COVID-19. This is due to the technique's intrinsic power to depict both structural and dynamic features of molecules; in this case, of the spike protein of SARS-CoV-2. By now, numerous cryo-EM studies have furthered our understanding of spike protein-angiotensin-converting enzyme 2 (ACE2) receptor interactions, which has informed the design of effective vaccines, and have enabled the characterization of neutralizing antibody binding sites, which will lead to the design of novel therapeutics as the virus evolves.