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10.1016/j.tibs.2021.10.005

http://scihub22266oqcxt.onion/10.1016/j.tibs.2021.10.005
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suck abstract from ncbi


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pmid34799235      Trends+Biochem+Sci 2022 ; 47 (2): 117-123
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  • Contributions of single-particle cryoelectron microscopy toward fighting COVID-19 #MMPMID34799235
  • Rapp M; Shapiro L; Frank J
  • Trends Biochem Sci 2022[Feb]; 47 (2): 117-123 PMID34799235show ga
  • Single-particle cryoelectron microscopy (cryo-EM), whose full capabilities have been realized only within the past decade, has had a pivotal role in the fight against COVID-19. This is due to the technique's intrinsic power to depict both structural and dynamic features of molecules; in this case, of the spike protein of SARS-CoV-2. By now, numerous cryo-EM studies have furthered our understanding of spike protein-angiotensin-converting enzyme 2 (ACE2) receptor interactions, which has informed the design of effective vaccines, and have enabled the characterization of neutralizing antibody binding sites, which will lead to the design of novel therapeutics as the virus evolves.
  • |*COVID-19[MESH]
  • |*Spike Glycoprotein, Coronavirus[MESH]
  • |Antibodies, Neutralizing/metabolism[MESH]
  • |Cryoelectron Microscopy[MESH]
  • |Humans[MESH]
  • |Protein Binding[MESH]


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