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10.1016/j.clim.2021.108879 http://scihub22266oqcxt.onion/10.1016/j.clim.2021.108879 34798239!8592856!34798239     free     free     free       Clin+Immunol 2021 ; 233 (ä): 108879 Nephropedia Template TP {{tp|p=34798239|t=2021. Role of NRF2 and Sirtuin activators in COVID-19 |pdf=|usr=}}{{34798239}} gab.com Text Role of NRF2 and Sirtuin activators in COVID-19 JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34798239 #FOAvip COVID-19 is a pandemic requiring immediate solution for treatment because of its complex pathophysiology. Exploration of novel targets and thus treatment will be life savers which is the need of the hour. 2 host factors- TMPRSS2 and ACE2 are responsible for the way the virus will enter and replicate in the host. Also NRF2 is an important protein responsible for its anti-inflammatory role by multiple mechanisms of action like inhibition of NF-kB, suppression of pro-inflammatory genes, etc. NRF2 is deacetylated by Sirtuins and therefore both have a direct association. Absence of SIRT indicates inhibition of NRF2 expression and thus no anti-oxidative and anti-inflammatory protection for the cell. Therefore, we propose that NRF2 activators and/or SIRT activators can be evaluated to check their efficacy in ameliorating the symptoms of COVID-19. Twit Text FOAVip Role of NRF2 and Sirtuin activators in COVID-19 ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34798239 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34798239 #FOAvip English Wikipedia <ref>{{Cite pmid|34798239}}</ref> Role of NRF2 and Sirtuin activators in COVID-19 #MMPMID34798239 Khan H; Patel S; Majumdar A Clin Immunol 2021[Dec]; 233 (ä): 108879 PMID34798239show ga COVID-19 is a pandemic requiring immediate solution for treatment because of its complex pathophysiology. Exploration of novel targets and thus treatment will be life savers which is the need of the hour. 2 host factors- TMPRSS2 and ACE2 are responsible for the way the virus will enter and replicate in the host. Also NRF2 is an important protein responsible for its anti-inflammatory role by multiple mechanisms of action like inhibition of NF-kB, suppression of pro-inflammatory genes, etc. NRF2 is deacetylated by Sirtuins and therefore both have a direct association. Absence of SIRT indicates inhibition of NRF2 expression and thus no anti-oxidative and anti-inflammatory protection for the cell. Therefore, we propose that NRF2 activators and/or SIRT activators can be evaluated to check their efficacy in ameliorating the symptoms of COVID-19. |Angiotensin-Converting Enzyme 2/immunology/metabolism[MESH] |Animals[MESH] |COVID-19/*immunology/metabolism/virology[MESH] |Host-Pathogen Interactions/immunology[MESH] |Humans[MESH] |NF-E2-Related Factor 2/*immunology/metabolism[MESH] |SARS-CoV-2/*immunology/metabolism/physiology[MESH] |Serine Endopeptidases/immunology/metabolism[MESH] |Sirtuins/*immunology/metabolism[MESH]Role of NRF2 and Sirtuin activators in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing