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10.1016/j.cell.2021.10.027 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.10.027 34798069!8564600!34798069     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (24): 5932-5949.e15 Nephropedia Template TP {{tp|p=34798069|t=2021. Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb |pdf=|usr=}}{{34798069}} gab.com Text Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=34798069 #FOAvip Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset of the sequence of pathobiological events leading to olfactory dysfunction remains obscure. Here, we have developed a postmortem bedside surgical procedure to harvest endoscopically samples of respiratory and olfactory mucosae and whole olfactory bulbs. Our cohort of 85 cases included COVID-19 patients who died a few days after infection with SARS-CoV-2, enabling us to catch the virus while it was still replicating. We found that sustentacular cells are the major target cell type in the olfactory mucosa. We failed to find evidence for infection of olfactory sensory neurons, and the parenchyma of the olfactory bulb is spared as well. Thus, SARS-CoV-2 does not appear to be a neurotropic virus. We postulate that transient insufficient support from sustentacular cells triggers transient olfactory dysfunction in COVID-19. Olfactory sensory neurons would become affected without getting infected. Twit Text FOAVip Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=34798069 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34798069 #FOAvip English Wikipedia <ref>{{Cite pmid|34798069}}</ref> Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb #MMPMID34798069 Khan M; Yoo SJ; Clijsters M; Backaert W; Vanstapel A; Speleman K; Lietaer C; Choi S; Hether TD; Marcelis L; Nam A; Pan L; Reeves JW; Van Bulck P; Zhou H; Bourgeois M; Debaveye Y; De Munter P; Gunst J; Jorissen M; Lagrou K; Lorent N; Neyrinck A; Peetermans M; Thal DR; Vandenbriele C; Wauters J; Mombaerts P; Van Gerven L Cell 2021[Nov]; 184 (24): 5932-5949.e15 PMID34798069show ga Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset of the sequence of pathobiological events leading to olfactory dysfunction remains obscure. Here, we have developed a postmortem bedside surgical procedure to harvest endoscopically samples of respiratory and olfactory mucosae and whole olfactory bulbs. Our cohort of 85 cases included COVID-19 patients who died a few days after infection with SARS-CoV-2, enabling us to catch the virus while it was still replicating. We found that sustentacular cells are the major target cell type in the olfactory mucosa. We failed to find evidence for infection of olfactory sensory neurons, and the parenchyma of the olfactory bulb is spared as well. Thus, SARS-CoV-2 does not appear to be a neurotropic virus. We postulate that transient insufficient support from sustentacular cells triggers transient olfactory dysfunction in COVID-19. Olfactory sensory neurons would become affected without getting infected. |Aged[MESH] |Anosmia[MESH] |Autopsy/*methods[MESH] |COVID-19/*mortality/physiopathology/*virology[MESH] |Endoscopy/methods[MESH] |Female[MESH] |Glucuronosyltransferase/biosynthesis[MESH] |Humans[MESH] |Immunohistochemistry[MESH] |In Situ Hybridization[MESH] |Male[MESH] |Microscopy, Fluorescence[MESH] |Middle Aged[MESH] |Olfaction Disorders[MESH] |Olfactory Bulb/*virology[MESH] |Olfactory Mucosa/*virology[MESH] |Olfactory Receptor Neurons/metabolism[MESH] |Respiratory Mucosa/*virology[MESH] |Respiratory System[MESH] |SARS-CoV-2[MESH]Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the r(epmc).pdf DeepDyve Pubget Overpricing