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10.1371/journal.pone.0259943 http://scihub22266oqcxt.onion/10.1371/journal.pone.0259943 34797868!8604354!34797868     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (11): e0259943 Nephropedia Template TP {{tp|p=34797868|t=2021. Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture |pdf=|usr=}}{{34797868}} gab.com Text Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34797868 #FOAvip Last year observed a global pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions of individuals worldwide. There is an urgent unmet need to provide an easily producible and affordable medicine to prevent transmission and provide early treatment for this disease. Since the nasal cavity and the rhinopharynx are the sites of initial replication of SARS-CoV-2, a nasal spray may be an effective option to target SARS-CoV-2 infection. In this study, we tested the antiviral action of three candidate nasal spray formulations against SARS-CoV-2 in vitro. We determined that iota-carrageenan in concentrations as low as 6 mug/mL inhibits SARS-CoV-2 in vitro. The concentrations of iota-carrageenan with activity against SARS-CoV-2 in vitro may be easily achieved through the application of nasal sprays as commonly used in several countries. Recently a double-blind, placebo-controlled study showed that iota-carrageenan in isotonic sodium chloride reduces ca. five times the risk of infection by SARS-CoV-2 in health care personnel. Further, xylitol at a concentration of 50 mg/mL (ca. 329 mM) was found to exert some antiviral action, though this preliminary finding needs further confirmation. Twit Text FOAVip Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34797868 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34797868 #FOAvip English Wikipedia <ref>{{Cite pmid|34797868}}</ref> Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture #MMPMID34797868 Bansal S; Jonsson CB; Taylor SL; Figueroa JM; Dugour AV; Palacios C; Vega JC PLoS One 2021[]; 16 (11): e0259943 PMID34797868show ga Last year observed a global pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions of individuals worldwide. There is an urgent unmet need to provide an easily producible and affordable medicine to prevent transmission and provide early treatment for this disease. Since the nasal cavity and the rhinopharynx are the sites of initial replication of SARS-CoV-2, a nasal spray may be an effective option to target SARS-CoV-2 infection. In this study, we tested the antiviral action of three candidate nasal spray formulations against SARS-CoV-2 in vitro. We determined that iota-carrageenan in concentrations as low as 6 mug/mL inhibits SARS-CoV-2 in vitro. The concentrations of iota-carrageenan with activity against SARS-CoV-2 in vitro may be easily achieved through the application of nasal sprays as commonly used in several countries. Recently a double-blind, placebo-controlled study showed that iota-carrageenan in isotonic sodium chloride reduces ca. five times the risk of infection by SARS-CoV-2 in health care personnel. Further, xylitol at a concentration of 50 mg/mL (ca. 329 mM) was found to exert some antiviral action, though this preliminary finding needs further confirmation. |Animals[MESH] |Antiviral Agents/pharmacology[MESH] |Carrageenan/*pharmacology[MESH] |Chlorocebus aethiops[MESH] |Nasal Sprays[MESH] |SARS-CoV-2/*drug effects[MESH] |Vero Cells[MESH]Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture (epmc).pdf DeepDyve Pubget Overpricing