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10.1371/journal.pcbi.1009560 http://scihub22266oqcxt.onion/10.1371/journal.pcbi.1009560 34793437!8601562!34793437     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Comput+Biol 2021 ; 17 (11): e1009560 Nephropedia Template TP {{tp|p=34793437|t=2021. Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections |pdf=|usr=}}{{34793437}} gab.com Text Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections JO: PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=34793437 #FOAvip Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is of zoonotic origin. Evolutionary analyses assessing whether coronaviruses similar to SARS-CoV-2 infected ancestral species of modern-day animal hosts could be useful in identifying additional reservoirs of potentially dangerous coronaviruses. We reasoned that if a clade of species has been repeatedly exposed to a virus, then their proteins relevant for viral entry may exhibit adaptations that affect host susceptibility or response. We perform comparative analyses across the mammalian phylogeny of angiotensin-converting enzyme 2 (ACE2), the cellular receptor for SARS-CoV-2, in order to uncover evidence for selection acting at its binding interface with the SARS-CoV-2 spike protein. We uncover that in rodents there is evidence for adaptive amino acid substitutions at positions comprising the ACE2-spike interaction interface, whereas the variation within ACE2 proteins in primates and some other mammalian clades is not consistent with evolutionary adaptations. We also analyze aminopeptidase N (APN), the receptor for the human coronavirus 229E, a virus that causes the common cold, and find evidence for adaptation in primates. Altogether, our results suggest that the rodent and primate lineages may have had ancient exposures to viruses similar to SARS-CoV-2 and HCoV-229E, respectively. Twit Text FOAVip Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections ????PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=34793437 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34793437 #FOAvip English Wikipedia <ref>{{Cite pmid|34793437}}</ref> Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections #MMPMID34793437 King SB; Singh M PLoS Comput Biol 2021[Nov]; 17 (11): e1009560 PMID34793437show ga Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is of zoonotic origin. Evolutionary analyses assessing whether coronaviruses similar to SARS-CoV-2 infected ancestral species of modern-day animal hosts could be useful in identifying additional reservoirs of potentially dangerous coronaviruses. We reasoned that if a clade of species has been repeatedly exposed to a virus, then their proteins relevant for viral entry may exhibit adaptations that affect host susceptibility or response. We perform comparative analyses across the mammalian phylogeny of angiotensin-converting enzyme 2 (ACE2), the cellular receptor for SARS-CoV-2, in order to uncover evidence for selection acting at its binding interface with the SARS-CoV-2 spike protein. We uncover that in rodents there is evidence for adaptive amino acid substitutions at positions comprising the ACE2-spike interaction interface, whereas the variation within ACE2 proteins in primates and some other mammalian clades is not consistent with evolutionary adaptations. We also analyze aminopeptidase N (APN), the receptor for the human coronavirus 229E, a virus that causes the common cold, and find evidence for adaptation in primates. Altogether, our results suggest that the rodent and primate lineages may have had ancient exposures to viruses similar to SARS-CoV-2 and HCoV-229E, respectively. |Adaptation, Physiological/genetics[MESH] |Amino Acid Substitution[MESH] |Angiotensin-Converting Enzyme 2/genetics/physiology[MESH] |Animals[MESH] |CD13 Antigens/genetics/physiology[MESH] |COVID-19/*genetics/*virology[MESH] |Common Cold/genetics/virology[MESH] |Computational Biology[MESH] |Coronavirus 229E, Human/genetics/physiology[MESH] |Coronavirus Infections/*genetics/*virology[MESH] |Evolution, Molecular[MESH] |Genomics[MESH] |Host Microbial Interactions/genetics/physiology[MESH] |Host Specificity/genetics/physiology[MESH] |Humans[MESH] |Mammals/genetics/virology[MESH] |Phylogeny[MESH] |Protein Interaction Domains and Motifs/genetics[MESH] |Receptors, Virus/genetics/physiology[MESH] |SARS-CoV-2/*genetics/physiology[MESH] |Selection, Genetic[MESH] |Spike Glycoprotein, Coronavirus/genetics/physiology[MESH]Comparative genomic analysis reveals varying levels of mammalian adapt(epmc).pdf DeepDyve Pubget Overpricing